grant
Impaired Sleep as a Target for Intervention Following Acute Organophosphate Intoxication
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Acetylcholine HydrolaseAcetylcholinesteraseAcuteAgricultureAmmon HornAnimalsAnticholinesterase AgentsAnticholinesterase DrugsAnticholinesterasesArchitectureAreaAutopsyBiological MarkersBrainBrain Nervous SystemCell DeathChemical WeaponsCholinesterase InhibitorsChronicChronic PhaseCognition DisordersCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommon Rat StrainsCommunitiesComplexCornu AmmonisDataData SetDevelopmentDiseaseDisorderDisturbance in cognitionDrugsDysfunctionEEGEarly InterventionElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EncephalonEngineering / ArchitectureEnzyme GeneEnzymesEpilepsyEpileptic SeizuresEpilepticsEvaluationEventFDA approvedFrequenciesFunctional disorderGeneralized Status EpilepticusGoalsHcrt proteinHcrt/ORXHcrts/ORXsHippocampusHistologyHistopathologyHourHumanImpaired cognitionImpairmentIndividualInsecticidesInterventionIntervention StrategiesIntoxicationLinkLiteratureLong-Term EffectsMaintenanceMeasurableMedicationMiceMice MammalsMissionModern ManMurineMusNatural HistoryNerve DegenerationNeurologic DeficitNeuron DegenerationNeurophysiology / ElectrophysiologyOrganophosphatesOutcomePharmaceutical PreparationsPhasePhenotypePhysiopathologyPlayRatRats MammalsRattusReceptor ProteinRecurrenceRecurrentResearchResearch SupportRodent ModelRoleSclerosisSeizure DisorderSeizuresSeveritiesSleepSleep ArchitectureSleep DisordersSleep Wake CycleSleep disturbancesStatus EpilepticusSymptomsSyndromeTestingTherapeutic InterventionValidationWaraberrant sleepacetylcholine acetylhydrolaseanalytical toolantagonismantagonistbio-markersbiologic markerbiomarkercholine esterase Icholinergiccognitive defectscognitive diseasecognitive disordercognitive dysfunctioncognitive functioncognitive losscognitive performancecognitive syndromedata pipelinedevelopmentaldisrupted sleepdisturbed sleepdrug/agentelectrophysiologicalepilepsiaepilepsy participantepilepsy patientepilepsy subjectepilepsy volunteerepileptic patientepileptic subjectepileptogenicexperiencehippocampalhypocretinhypocretin/orexinhypocretins/orexinsimpaired sleepimprovedimprovement on sleepintervention therapyirregular sleeplong-term sequelaemass casualtymeetingmeetingsnecrocytosisnecropsyneural degenerationneural inflammationneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetorexinpathophysiologypatients with epilepsypostmortempreventpreventingreceptorsleep diseasessleep disruptionsleep dysfunctionsleep dysregulationsleep illnesssleep improvementsleep problemsleep to wake transitionsleep to wakefulness transitionsleep wakefulness cyclesleep/wake disruptionsleep/wake disturbancesleep/wake transitionssocial roletherapeutic targettooluser-friendlyvalidationsvigilance
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Description preview
Organophosphate cholinesterase inhibitors (OPs) were developed as agricultural insecticides and adapted to
function as chemical weapons. OPs inhibit the acetylcholinesterase enzyme and acute intoxication can lead to
a cholinergic crisis, status epilepticus (SE) and, for individuals who survive, the development of spontaneous
recurrent seizures…
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