grant

Impact of whole-body radiation exposure on pathogen-specific memory CD8 T cells

Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 10 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AccidentsAcuteAcute Radiation SyndromeAntigensAtomic EnergyBloodBlood CirculationBlood Reticuloendothelial SystemBloodstreamBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCD62LCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCancersCarbonCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell CountCell DeathCell FunctionCell Mediated ImmunologyCell NumberCell PhysiologyCell ProcessCell-Mediated ImmunityCellsCellular FunctionCellular ImmunityCellular PhysiologyCellular ProcessChemotactic CytokinesChestChimeraChimera organismChronicCytolysisDataDevelopmentDevelopment and ResearchDiagnosticDoseElectricityElementsEnergy-Generating ResourcesExhibitsExposure toFailureFossil FuelsGenerationsGoalsHLHRCHSC transplantationHealthHeart VascularHematologyHematopoietic Cell TumorHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsHeterogeneityHomologous Chemotactic CytokinesHumanImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmune systemImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImpairmentIndustryInfectionInflammationInflammatoryInfluenza VirusIntercrinesInvadedIonizing Electromagnetic RadiationIonizing radiationJobsKnowledgeLAM-1 geneLCM VirusesLCMVLECAM1LNHRLSELLYAM-1LYAM1LaboratoriesLength of LifeLiteratureLongevityLungLung Respiratory SystemLymphaticLymphatic TissueLymphocytic choriomeningitis virusLymphoid TissueLysisMaintenanceMalignant CellMalignant Hematopoietic NeoplasmMalignant NeoplasmsMalignant TumorMaterials TestingMediatingMediatorMedicalMemoryModalityModelingModern ManMolecularNatureNuclear EnergyNuclear ReactorsOccupationsOutcomePatientsPhenotypePopulationPredispositionProductionProfessional PositionsProgenitor Cell TransplantationProliferatingR & DR&DRadiationRadiation DoseRadiation Dose UnitRadiation ToxicityRadiation exposureRadiation induced damageRadiation-Ionizing TotalRadiotoxicityRecoveryRegimenReportingResistanceSELL geneSIS cytokinesSecondary toSelectin L GeneSiteSkinSourceStem Cell TransplantationStem cell transplantSterilizationSubcellular ProcessSurvey InstrumentSurveysSurvivorsSusceptibilityT cell responseT memory cellT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT8 CellsT8 LymphocytesTQ-1ThoraceThoracicThoraxTissuesTotal Body IrradiationUniversitiesVaccinesViral DiseasesVirusVirus DiseasesWhole-Body IrradiationWhole-Body Radiationacute infectionarmblood cancerblood stem cell transplantationcancer cellcancer of bloodcancer of the bloodchemoattractant cytokinechemokinechemotherapychimerascirculatory systemcombatconditioningcytokinedevelopmentalenergy sourceexhaustexposed human populationgastrointestinalhematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitor cell transplantationhost responsehuman exposureimmune system responseimmunogenimmunoresponseinfluenzavirusinterestionizing outputirradiationmalignancymedical countermeasurememory T lymphocytenecrocytosisneoplasm/cancerpathogenprogenitor transplantationradiation damageradiation effectradiation poisoningrapid detectionrecruitresearch and developmentresistantresponsestem and progenitor cell transplantationsthymus derived lymphocytevaccine strategyviral infectionvirus infectionvirus-induced disease
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Description preview

Accidental or deliberate radiation exposure of humans remains a major health concern, due to the paucity of
medical countermeasures (MCMs) to ameliorate radiation-induced damage. While high dose radiation

exposure is generally fatal, even low dose whole body (WBI) or partial radiation exposure can have acute-

and/or delayed- negative impacts that…

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