grant
Impact of prenatal opioid exposure on corticostriatal circuits that modulate alcohol-related behaviors
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years oldAMPA ReceptorsAblationAbstinenceAdanonAddressAffectAlcohol Chemical ClassAlcohol DrinkingAlcohol abuseAlcohol consumptionAlcoholsAlthoseAnatomic SitesAnatomic structuresAnatomyAnteriorAwardBehavioralBiochemicalBirthBrainBrain Nervous SystemBrain regionChildChild YouthChildren (0-21)ClinicalClinical ResearchClinical StudyConfocal MicroscopyConnector NeuronCorpus StriatumCorpus striatum structureDataDolophineDorsalElectrophysiologyElectrophysiology (science)EncephalonEtOH abuseEtOH drinkingEtOH useExposure toFemaleFetal TissuesFutureGlutamatesGrantHeavy DrinkingHistoryHomeHydrogen OxideIncidenceIndividualInstitutionIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronKnowledgeL-GlutamateLabelLaboratoriesLiteratureLong-Term DepressionLong-Term Synaptic DepressionMeasurementMeasuresMediatingMethadoneMethadoseMiceMice MammalsMicroscopyModelingMolecularMorbidityMorbidity - disease rateMothersMurineMusN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNMDA Receptor-Ionophore ComplexNMDA ReceptorsNeonatalNerve CellsNerve UnitNetwork AnalysisNeural CellNeural TransmissionNeurocyteNeuronsNeurophysiology / ElectrophysiologyOpiate AddictionOpiate DependenceParturitionPathway AnalysisPathway interactionsPhosphorylationPhysiologicPhysiologicalPopulationPredispositionPregnant WomenPrevalenceProtein PhosphorylationProteinsProteomeProteomicsRecording of previous eventsReplacement TherapyReporterResistanceRewardsRoleSaccharoseSalineSaline SolutionShapesSliceSourceStriate BodyStriatumSucroseSusceptibilitySynapsesSynapticSynaptic TransmissionSynaptic plasticityTestingTimeTransmissionWaterWorkalcohol behavioralcohol co-abusealcohol effectalcohol exposedalcohol exposurealcohol induced behavioralcohol ingestionalcohol intakealcohol problemalcohol product usealcohol related behavioralcohol responsealcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakebehavior responsebehavioral responsebinge alcohol consumptionbinge drinkingcell typeclinical relevanceclinically relevantdensitydrink heavilydrinkingdrinking behaviorelectrophysiologicalepisodic drinkingethanol abuseethanol behaviorethanol consumptionethanol drinkingethanol effectethanol exposedethanol exposureethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol related behaviorethanol responseethanol useethanol use disorderexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionexpectant motherexpectant womenexpecting motherexpecting womenexperienceexposed in uteroexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolextreme drinkingfetal exposurefetal opiate exposuresfetal opioid exposurefetus tissuefocus on malefocused on mengestational opiate exposuregestational opioid exposuregestational opioid useglutamatergichazardous alcohol useheavy alcohol usehistorieshomesin utero exposurein vivoindividuals who are pregnantinsightinterdisciplinary approachintra-uterine environmental exposureintrauterine environmental exposurekidslicit opioidmalemale focusedmale specificmale targetedmortalitymouse modelmultidisciplinary approachmurine modelneuralneuronalnon-medical opioid usenonmedical opioid usenoveloffspringopiate consumptionopiate drug useopiate exposureopiate intakeopiate medicationopiate misuseopiate useopiate use disorderopiate use in pregnancyopiate withdrawalopioid addictionopioid consumptionopioid dependenceopioid dependentopioid detoxopioid detoxificationopioid drug useopioid exposureopioid intakeopioid medicationopioid misuseopioid useopioid use disorderopioid use in pregnancyopioid withdrawalopioids during pregnancyopioids in pregnancyopoid use during pregnancyoptogeneticspathwaypeople who are pregnantphospho-proteomicsphosphoproteomicspostsynapticpre-clinical studypreclinical studypregnant femalespregnant motherspregnant peoplepregnant populationsprenatalprenatal exposureprenatal opiate exposureprenatal opioid exposureprenatal opioid useprenatal screeningprenatal testingprenatally exposedprenatally opiate exposedprescribed opiateprescribed opioidprescription opiateprescription opioidpresynapticproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol usepsychostimulant misusereceptor functionresilienceresilientresistantresponseresponse to alcoholresponse to ethanolsocial rolestandard of carestimulant misusestriatalsubstance misusesubstance usesubstance usingsynapsesynapse functionsynapse inhibitionsynaptic functionsynaptic inhibitionsynergismtargeted to menthose who are pregnanttransmission processunbornwirelesswomen who are pregnantyoungster♀♂
Description preview
Project Summary
The number of children born to opioid-dependent mothers has increased over 300% in the past two decades.
As abstinence from opioids during pregnancy is not recommended, opioid medication replacement therapy, such
as methadone, represents the standard of care for pregnant women with opioid use disorder thus perpetuating
the birth of…
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