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Impact of preanalytical conditions on functional cancer biomarkers

Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Aug 2025Deadline 26 Sept 2025 ⚠️

NIHUS FederalResearch GrantFY20253D cell culture3D cultureAbscissionAccelerationApoptoticArtifactsBiological MarkersBiopsyCancer PatientCancersCell BodyCell Communication and SignalingCell CountCell Culture TechniquesCell NumberCell SignalingCellsChemical ExposureClinicClinicalCore BiopsyCore Needle BiopsyCryofixationCryopreservationCulture MediaCultured Neoplastic CellsCultured Tumor CellsDissociationDistantDrug ExposureDrugsExcisionExtirpationFreezingHourHumanIntracellular Communication and SignalingMalignant CellMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMathMath ModelsMathematicsMeasurementMeasuresMedicationModern ManMolecularMorphologic artifactsOncologyOncology CancerOperative ProceduresOperative Surgical ProceduresOutcomeOutputOvarianOvarian TumorOvary CancerOvary NeoplasmsOvary TumorPDX modelPatient derived xenograftPatientsPerformancePharmaceutical PreparationsPhenotypeProtocolProtocols documentationRampRefractoryRelapseRemovalReproducibilitySamplingSelection for TreatmentsSignal TransductionSignal Transduction SystemsSignalingSiteSolidSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurvival RateTemperatureTherapeuticTrainingTumor CellVariantVariationWorkbio-markersbiologic markerbiological signal transductionbiomarkercancer biomarkerscancer cellcancer markerscell culturecell cultureschemical librarychemotherapycold preservationcold storagedrug preservationdrug sensitivitydrug/agentgrowth mediahuman tissueimprovedindividual patientmalignancymathematic modelmathematical modelmathematical modelingneoplasm/cancerneoplastic cellovarian cancerovarian neoplasmpatient derived xenograft modelpatient responsepatient specific responseprecision medicineprecision-based medicineresectionresponseresponsive patientselection of treatmentsmall molecule librariessurgerytherapy selectionthree dimensional cell culturetooltreatment selectiontumor

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PROJECT SUMMARYABSTRACT
An attractive approach to improve the survival of ovarian cancer patients is to identify the ideal therapy for each
tumor. Functional precision medicine (FPM) represents an emerging class of biomarker where the ideal therapy
is selected by directly exposing patient tumor cells to potential drug options followed by molecular…

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