grant
Impact of polymicrobial interactions and within-host adaptation on CAUTI pathogenesis
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 9 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AddressAgeAllelesAllelomorphsAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAntimicrobial ResistanceArchitectureBacteriuriaBiological Specimen BanksBiological Substance BanksBladderBladder Urinary SystemCatheterizationCathetersCessation of lifeClinicalCodependenceCodependencyDNA mutationDataDeathDeath RateDevelopmentDiseaseDisorderE coliE faecalisE. coliE. faecalisEngineering / ArchitectureEnterococcus faecalisEnvironmentEscherichia coliExhibitsExpression SignatureGene Expression ProfileGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGenotypeGrowthHealthHealth CareHealth ExpendituresImmunologic StimulationImmunological StimulationImmunostimulationImplantable CathetersIn-Dwelling CathetersIncidenceIndividualIndwelling CatheterInfectionInnate Immune ResponseInvestigationKnowledgeLifeMDR organismMDR pathogenMediatorMiceMice MammalsMicrobeMicrobial BiofilmsMicrobiologyMiscellaneous AntibioticMissionModelingMorbidityMorbidity - disease rateMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMurineMusMutationNational Institutes of HealthNursing HomesOlder PopulationOut-patientsOutpatientsP mirabilisP. mirabilisParticipantPathogenesisPathogenicityPatientsPhenotypePhysiologicPhysiologicalProteomicsProteus mirabilisPublicationsPyelonephritisRNA SeqRNA sequencingRNAseqResearchResearch ResourcesResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistance to antibioticsResistant to Multiple DrugResistant to antibioticsResistant to multi-drugResistant to multidrugResourcesS faecalisS. faecalisScientific PublicationSeveritiesSeverity of illnessStreptococcus Group DStreptococcus faecalisTestingTissue GrowthUnited States National Institutes of HealthUrinary CatheterizationUrinary tractUrinary tract infectionUrinary tract infectious diseaseUrineVenous Reservoirsagesanti-microbial agentanti-microbial druganti-microbial resistantantibiotic drug resistanceantibiotic resistantbiofilmbiofilm communitybiological specimen repositorybiosample repositorybiospecimen bankbiospecimen repositorycatheter associated UTIcatheter associated urinary tract infectioncatheterized urinecommunity microbesdamage to kidneydevelopmentaldisease severitydrug resistant microbesdrug resistant microorganismdrug-resistant microbesfitnessgene expression patterngene expression signaturegenome mutationhealth care associated infectionshealth care expenditurehigh riskinnovateinnovationinnovativeinterestkidney damagekidney infectionmedical expendituremicrobe communitymicrobial communitymicroorganism communitymixed species biofilmmortality ratemortality ratiomouse modelmulti-drug resistantmulti-drug resistant organismmulti-drug resistant pathogenmulti-microorganism biofilmmultidrug resistantmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogenmultispecies biofilmmurine modelnursing homeolder adultolder adulthoodolder groupsolder individualsolder personontogenypathogenpolymicrobial biofilmpolymicrobial communitypolymicrobial diseasepreventpreventingrenal damageresistance to anti-microbialresistantresistant to antimicrobialsample collectionspecimen bankspecimen collectionspecimen repositorytranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtreatment strategytrendurinaryurinary bladderurinary infectionurinary sepsisurinary tract catheter infectionurosepsis
Description preview
Project Summary/Abstract
Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of morbidity
and healthcare expenditures across all ages. Older adults and individuals with catheters have a particularly high
risk of UTI sequelae, including kidney infection, permanent renal damage, and urosepsis. The average…
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