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Impact of lymph node sparing on the anti-tumor response for head and neck cancer treated with radiation and immunotherapy
Organization COLORADO STATE UNIVERSITYLocation FORT COLLINS, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AffectAgonistAnimal ModelAnimal Models and Related StudiesAntigensAntitumor ResponseArchivesAssayAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBioassayBiological AssayBloodBlood Reticuloendothelial SystemBoard CertificationCD134CD8CD8BCD8B1CD8B1 geneCancer ModelCancer PatientCancerModelCanine SpeciesCanis familiarisCarcinomaCell BodyCell DensityCellsClinicalClinical DataClinical Treatment MoabCombination immunotherapyCombined Modality TherapyCytotoxic cellDataDogsDogs MammalsDoseEpithelial cancerEuropeFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGoalsHNC patientHead and Neck CancerHead and Neck CarcinomaHumanImmuneImmune mediated therapyImmune responseImmunesImmunityImmunochemical ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyInflammatoryK lymphocyteLYT3LigandsLymph Node Reticuloendothelial SystemLymph Node TissueLymph node properLymphatic nodesMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Head and Neck NeoplasmMentorshipMetastasisMetastasis to Lymph NodesMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to Lymph NodesMetastatic TumorMetastatic Tumor to Lymph NodesMiceMice MammalsModern ManMonoclonal AntibodiesMouth CarcinomaMultimodal TherapyMultimodal TreatmentMurineMusNK CellsNatural Killer CellsNeoplasm MetastasisOX40Oral Cavity CarcinomaPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhenotypePhysiciansPopulationPre-Clinical ModelPreclinical ModelsPreclinical dataPrimary NeoplasmPrimary TumorPrognosisProgram DevelopmentRNA SeqRNA sequencingRNAseqRadiationRadiation OncologistRadiation therapyRadiotherapeuticsRadiotherapyRegulatory T-LymphocyteReportingResearchRodentRodentiaRodents MammalsRoleSamplingScientistSecondary NeoplasmSecondary TumorSiteT cell responseT-Cell DepletionT-cell depletion therapyT-lymphocyte depletion therapyTeff cellTestingTreatment outcomeTregTumor CellTumor ImmunityUnited Statesadvanced diseaseadvanced illnessanti-tumor immune responseanti-tumor immune therapyanti-tumor immunityanti-tumor immunotherapyanti-tumor responseantigen-specific T cellsantitumor immunitycancer immunitycancer metastasiscancer microenvironmentcaninecanine animal modelcanine modelcareercareer developmentclinical relevanceclinically relevantcombination therapycombinatorial immunotherapycombined modality treatmentcombined treatmentcomparativedesigndesigningdog modeldomestic dogdraining lymph nodedrivingdual immunotherapyeffector T cellepithelial carcinomaexperimentexperimental researchexperimental studyexperimentsflow cytophotometryhead and neck cancer patienthead/neck cancerhigh riskhost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoresponseimmunosuppressedimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedimproved outcomeinnovateinnovationinnovativeinterestirradiationlymph glandlymph node metastasislymph nodeslymphnodesmAbsmalignant head and neck tumormodel of animalmonoclonal Absmouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm immunotherapyneoplastic cellnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyoral carcinomapathwaypatient oriented outcomespatient responsepatient specific responsepreclinical findingspreclinical informationradiation effectradiation treatmentregional lymph noderegulatory T-cellsresponsive patientsocial rolestandard of caretranscriptome sequencingtranscriptomic sequencingtranslational cancer researchtranslational investigatortranslational researchertranslational scientisttreatment with radiationtumortumor cell metastasistumor growthtumor immune therapytumor immunotherapytumor microenvironment
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Description preview
Abstract
As a board-certified veterinary radiation oncologist and radiobiologist, I am committed to, and excited for, a
career in translational cancer research as a physician scientist. My long-term career goal is to develop into an
independent veterinary clinician scientist, proficient in designing and performing innovative radiation research,…
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