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Impact of local network dynamics on visual cortex function

Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Apr 2013Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY20252-photonASDAddressAdolescentAdolescent YouthAgeAnatomic SitesAnatomic structuresAnatomyAutismAutistic DisorderBehavioralBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsConnector NeuronCyclic SomatostatinDataDendritesDevelopmentDiseaseDisorderDysfunctionEarly Infantile AutismElectrophysiologyElectrophysiology (science)EncephalonEpilepsyEpileptic SeizuresEpilepticsEquilibriumExhibitsEyeEyeballFunctional disorderGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingInvestigationKanner's SyndromeLifeMaintenanceMethodologyMiceMice MammalsMonitorMurineMusNeocortexNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyPeptidesPharmacologyPhysiopathologyPlayPopulationPrimary visual cortexPyramidal neuronRegulationRoleSRIHSRIH-14SchizophreniaSchizophrenic DisordersSeizure DisorderSensorySignal TransductionSignal Transduction SystemsSignalingSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneStimulusStriate CortexStriate areaSynapsesSynapticTestingTimeVisualVisual Cortexadult animalagesarea striataautism spectral disorderautism spectrum disorderautistic spectrum disorderaxon signalingaxon-glial signalingaxonal signalingbalancebalance functionbiological signal transductioncellular targetingdementia praecoxdevelopmentaldisease modeldisorder modelelectrophysiologicalepilepsiaepileptogenicexperimentexperimental researchexperimental studyexperimentsglia signalingglial signalinggrowth hormone release inhibiting factorhippocampal pyramidal neuronhomotypical cortexin vivoinnervationinsightisocortexjuvenilejuvenile humanmature animalmicroscope imagingmicroscopic imagingmicroscopy imagingneocorticalneopalliumnerve signalingnerve supplyneural controlneural regulationneural signalingneurodevelopmental diseaseneuromodulationneuromodulatoryneuronalneuronal signalingneuropsychiatric diseaseneuropsychiatric disorderneuroregulationneurotransmissionoptogeneticspathophysiologypharmacologicpost-natal developmentpost-natal periodpostnatalpostnatal developmentpostnatal periodpostsynapticresponseschizophrenicsocial rolesynapsetwo-photonvision developmentvisual corticalvisual developmentvisual processvisual processingvisual receptive fieldvisual system development

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Description preview

PROJECT SUMMARY
GABAergic interneurons are central to the normal development and function of neocortical circuits. In
particular, cells that express the peptide somatostatin (SST-INs) are thought to play critical roles in both
spontaneous and sensory-evoked neuronal activity, primarily via their robust inhibition of the dendrites of
excitatory…

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