grant
Impact of lipids and food on oral compound absorption: mechanistic studies and modeling
Organization NORTHEASTERN UNIVERSITYLocation BOSTON, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Alimentary CanalCirculationClinicalComplexDangerousnessDevelopmentDigestive TractDrug DeliveryDrug Delivery SystemsDrugsEngineeringEnsureFoodFormulationGI TractGastrointestinal TractGastrointestinal tract structureGoalsHealthHumanIndustrializationIngestionInjectionsInterdisciplinary ResearchInterdisciplinary StudyIntestinalIntestinal MucosaIntestinesKineticsLaboratoriesLipidsLymphMathMathematicsMedicationModelingModern ManMucosaMucosal TissueMucous MembraneMultidisciplinary CollaborationMultidisciplinary ResearchNutrientOralOral IngestionOutcomes ResearchPharmaceutical PreparationsPositionPositioning AttributeProcessResearch ResourcesResourcesStructureSystemToxinTranslatingabsorptionalimentary tractbowelcomputer based predictiondesigndesigningdevelopmentaldigestive canaldrug developmentdrug/agentexperienceingestlymphatic fluidpatient populationpredictive modeling
Description preview
Lipids in drug delivery systems and food can have a tremendous impact on the systemic absorption of orally
delivered compounds, including drugs, nutrients, and toxins. However, this impact cannot be quantitatively
predicted a priori, and underlying mechanisms are poorly understood. The ability to quantitatively predict the
impact of lipids in drug…
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