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Impact of LAG3 on CD8+ T cell motility and migration in the context of cancer immunotherapy
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025ActinsAddressAntigensAssayB9 endocrine pancreasBindingBioassayBiological AssayCAKBCAKbetaCD4 AntigensCD4 MoleculeCD4 ProteinCD4 ReceptorsCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell LocomotionCell MigrationCell Migration AssayCell MovementCell SignalingCell-Mediated Lympholytic CellsCell-to-Cell InteractionCellsCellular MatrixCellular MigrationCellular MotilityCheckpoint inhibitorChemokine Receptor GeneClinicalCytolytic T-CellCytoplasmCytoplasmic DomainCytoplasmic TailCytoskeletal SystemCytoskeletonCytotoxic T CellCytotoxic T-LymphocytesDysfunctionEndocrine PancreasFAK2FamilyFocal Adhesion Kinase 1Functional disorderGoalsImmuneImmune checkpoint inhibitorImmune mediated therapyImmunesImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyImpairmentIn SituIn VitroInfiltrationIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingIslands of LangerhansIslets of LangerhansLYT3LengthMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant CellMalignant MelanomaMediatingMelanomaMelanoma TumorMiceMice MammalsMicroscopyMigration AssayModelingMolecular InteractionMotilityMurineMusNesidioblastsOKT4 antigenPD 1PD-1PD-1 antibody therapyPD-1 therapyPD1PD1 antibody therapyPD1 based treatmentPTK2 Protein Tyrosine Kinase 2PTK2BPTK2B genePYK2Pancreatic IsletsPars endocrina pancreatisPathway interactionsPatientsPhosphorylationPhysiopathologyPlasmidsPlayPolymersProgression-Free SurvivalsProtein PhosphorylationReceptor ProteinReceptor SignalingRoleSeriesSignal TransductionSignal Transduction SystemsSignalingSolid NeoplasmSolid TumorSurfaceSurface CD4 ReceptorsSystemT cell infiltrationT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT4 moleculeT8 CellsT8 LymphocytesTestingTherapeuticTumor CellTumor ImmunityTumor growth in melanomaWorkaPD-1 therapyaPD-1 treatmentaPD1 therapyaPD1 treatmentactivate T cellsanti-PD-1 therapyanti-PD-1 treatmentanti-PD1 therapyanti-PD1 treatmentanti-cancer immunotherapyanti-programmed cell death 1 therapyanti-programmed cell death protein 1 therapyanti-tumor immunityanticancer immunotherapyantitumor immunityautoimmune reactivityautoreactivitybiological signal transductioncancer cellcancer immune therapeuticscancer immunitycancer immunotherapeuticscancer immunotherapycancer infiltrating T cellscancer microenvironmentcancer typecell adhesion kinase betacell motilitycheck point immunotherapycheck point inhibitor therapycheck point inhibitory therapycheck point therapycheckpoint immunotherapycheckpoint inhibitor therapycheckpoint inhibitory therapycheckpoint therapychemokine receptorendogenous substrate pp120focal adhesion kinasefocal adhesion protein tyrosine kinasefocal adhesion-associated protein tyrosine kinase pp125FAKhelper T lymphocyte markerimaging approachimaging based approachimmune check point inhibitorimmune check point therapyimmune checkpoint therapyimmune drugsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentimmunotherapy for cancerimmunotherapy of cancerimprovedin vivointra-vital imagingintra-vital microscopyintracellular skeletonintravital imagingintravital microscopykiller T cellmelanoma cancer modelmelanoma modelmelanoma tumor modelmigrationmulti-photonmutantneoplastic cellnovelpathophysiologypathwaypolymerpolymericpolymerizationprogrammed cell death 1programmed cell death protein 1programmed cell death protein 1 therapyprogrammed death 1proline-rich tyrosine kinase 2receptorreceptor expressionresponserestraintsle2social rolespectral imagespectral imageryspectrographspectrum imagespectrum imagerysuperresolution microscopysystemic lupus erythematosus susceptibility 2targeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthymus derived lymphocytetumortumor infiltrating T cellstumor microenvironmentvector
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ABSTRACT
CD8+ T cells play a critical role in antitumor immunity and recent therapeutic strategies targeting CD8+
T cells have shown unprecedented efficacy in treating a growing number of cancer types. One leading
strategy involves the use of immune checkpoint inhibitor (ICI) therapies. ICI therapy works by interfering
with inhibitory receptors…
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