grant

Impact of Circadian Misalignment for Adolescents with ADHD: Observational and Mechanistic Data

Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 5 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY202612-20 years old13 year old13 years of age21+ years oldAD/HDADHDAddressAdherenceAdolescenceAdolescentAdolescent YouthAdultAdult HumanAgeAttentionAttention deficit hyperactivity disorderBehaviorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiological ClocksCircadian RhythmsCircadian desynchronyClinical TrialsConcurrent StudiesConditioning TherapyDataDrowsinessDrugsExecutive DysfunctionExecutive Function DeficitExecutive ImpairmentFunctional impairmentFutureImpairmentIndividualIndividual DifferencesInterventionLightLinkMedicationMelatoninMethodsMoodsNyctohemeral RhythmOutcomeOwlsPerformancePersonsPharmaceutical PreparationsPhasePhotoradiationPopulationPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPsychopathologyRaceRacesResearchRiskRoleScheduleSchoolsSleepSocio-economic statusSocioeconomic StatusSomnolenceStimulantStrigiformesSymptomsTestingTimeTreatment EffectivenessTwenty-Four Hour Rhythmabnormal psychologyadolescence (12-20)adulthoodadverse consequenceadverse outcomeage 13age 13 yearsagesassociated symptombehavior interventionbehavioral interventionbiological sexbody clockcircadiancircadian desynchronizationcircadian misalignmentcircadian processcircadian rhythmicityco-morbidco-morbid symptomco-morbidityco-occuring symptomcomorbid symptomcomorbidityconcurrent symptomcooccuring symptomcostdaily biorhythmdevelop therapydrug/agentemotion dysregulationemotion regulationemotional dysregulationemotional regulationfunctional disabilityfunctional outcomeshigh riskimprovedinattentioninattentivenessindexinginsightinternal clockintervention developmentjuvenilejuvenile humanpeerpoor sleeppsychiatric co-morbiditypsychiatric comorbiditypsychosocialquality of sleepracialracial backgroundracial originsexsleep amountsleep controlsleep durationsleep episodesleep intervalsleep lengthsleep periodsleep qualitysleep quantitysleep regulationsleep timesleep/wake regulationsleepinesssocialsocial rolesocio-economic positionsocioeconomic positionsuccesssymptom associationsymptom comorbiditytherapy developmentthirteen year oldthirteen years of agetime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtreatment development
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PROJECT SUMMARY
During adolescence, individuals with attention-deficit/hyperactivity disorder (ADHD) often show escalating

academic and social impairments and comorbid psychopathology, a rapid decline in medication use and

adherence, less engagement in psychosocial treatments, and limited data to guide those treatments. Sleep

has emerged as a…

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Impact of Circadian Misalignment for Adolescents with ADHD: Observational and Mechanistic Data — CINCINNATI CHILDRENS HO | Dev Procure