grant
Impact of Circadian-Microbiome Interaction on the Gut-Pancreas Axis in Aging
Organization UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONLocation HOUSTON, UNITED STATESPosted 1 Aug 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AddressAffectAgeAge related pathologiesAgingAnimalsAutoregulationBacterial TranslocationBiologicalBiological RhythmCancer InductionCancersCausalityCell Communication and SignalingCell SignalingChronicChronic DiseaseChronic IllnessCircadian DysregulationCircadian RhythmsCollectionCuesDataDepositDepositionDiabetes MellitusDietDysfunctionEatingElderlyEpitheliumEtiologyExposure toFatsFatty acid glycerol estersFoodFood IntakeFreedomFunctional disorderFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGeneticHomeostasisHumanImpairmentIndividualInfiltrationInflammagingInflammationInjuryInsulin ResistanceInterventionIntestinalIntestinal LeakageIntestinesIntracellular Communication and SignalingKnowledgeLeaky GutLibertyLife StyleLifestyleLinkMalignant NeoplasmsMalignant TumorMediatingMiceMice MammalsMicrobeModern ManModernizationMurineMusNyctohemeral RhythmOlder PopulationOrganOrganoidsPancreasPancreaticPancreatic InjuryPancreatic TraumaPathway interactionsPeripheralPhenotypePhysiological HomeostasisPhysiologyPhysiopathologyProxyQOLQuality of lifeRiskRoleSignal TransductionSignal Transduction SystemsSignalingSocietiesSurfaceSystemTimeTwenty-Four Hour RhythmWorkaccelerated agingaccelerated biological ageaccelerated biological agingadvanced ageage accelerationage associated diseaseage associated disorderage associated impairmentage associated pathologiesage dependent diseaseage dependent disorderage dependent impairmentage dependent pathologiesage groupage induced pathologiesage related human diseaseage related pathwaysage-related diseaseage-related disorderage-related impairmentage-related inflammationaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging associated diseaseaging associated disordersaging associated inflammationaging associated mechanismaging associated pathologiesaging dependent pathologiesaging induced pathologiesaging mechanismaging pathologiesaging pathwayaging populationaging preventionaging processaging related diseaseaging related disordersaging related mechanismaging related pathologiesaging related pathwaysaging resilienceanti aginganti geronicantiagingattenuated insulin secretionbiologicbiological mechanism of agebiological pathways of agebiological signal transductionblunted insulin secretionbowelbowel inflammationcarcinogenesiscausationchronic disordercircadiancircadian abnormalitycircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian processcircadian rhythmicitycohortdaily biorhythmdecreased insulin releasedecreased insulin secretiondefective insulin secretiondiabetesdietsdigestive tract microbiomediminished insulin releasediminished insulin secretiondisease associated with agingdisease causationdisease of agingdisorder of agingdisorders associated with agingdisorders related to agingdysbacteriosisdysbiosisdysbioticeating cuesenteric microbial communityenteric microbiomeenteric microbiotaepidemiology research studyepidemiology studyepidemiology surveyexperienceexperimentexperimental researchexperimental studyexperimentsfood cuesgastrointestinal microbial floragastrointestinal microbiomegeriatricgut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehealthy aginghealthy human aginghost microbiomehunger cuesimpaired insulin releaseimpaired insulin secretioninadequate insulin releaseinadequate insulin secretioninflamed bowelinflamed gutinflamed intestineinflamm-ageinginflamm-aginginflammation associated with aginginjuriesinjury to organsinsightinsulin resistantinsulin toleranceintestinal barrierintestinal biomeintestinal floraintestinal inflammationintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal mucosal barrierintestinal tract microfloralife spanlife-style factorlifespanlifestyle factorslowered insulin secretionmalignancymechanism regulating agingmechanisms involved in agingmicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiotamicrofloramultiorgan injurymultispecies consortianeoplasm/cancernovelolder groupsolder individualsolder personorgan injurypathophysiologypathwaypathway involved in agingpopulation agingpreventprevent age relatedprevent agingpreventingprophylacticreduced insulin releaseresilienceresilience during agingresilience in agingresilience in normal agingresilience to agingresilience with agingresilientresilient agingresilient to agingresponsesenior citizensocial rolesuppress agingsuppressed insulin releasesuppressed insulin secretionsystemic inflammationsystemic inflammatory response
Description preview
Abstract
Low grade systemic inflammation (or inflammaging) associates with many age-associated diseases.
Among the mechanisms that incite inflammaging, damage to the intestinal barrier is likely among the most
important. As a common feature of aging, several studies have indicated a close connection between intestinal
barrier dysfunction, changes…
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