grant
Immunotherapy of inflammation, autoimmune disease and cancer
Organization NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCHLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Animal ModelAnimal Models and Related StudiesAntigensApoptosisApoptosis PathwayAutoimmune DiseasesAutoimmune StatusAutoimmunityAutoregulationBone-Derived Transforming Growth FactorBuccal CavityBuccal Cavity Head and NeckCancersCavitas OrisCell BodyCellsCellular Immune FunctionCellular Metabolic ProcessChronicDevelopmentDiseaseDisorderExperimental Animal ModelExperimental ModelsFutureGoalsHomeostasisImmune ToleranceImmune mediated therapyImmune responseImmune systemImmunityImmunologic ToleranceImmunologically Directed TherapyImmunotherapyInflammationIntermediary MetabolismKnowledgeMacrophageMalignant NeoplasmsMalignant TumorMetabolic ProcessesMetabolic syndromeMetabolismMilk Growth FactorMouthMφOral cavityPathogenesisPatientsPhysiological HomeostasisPlatelet Transforming Growth FactorProgrammed Cell DeathRegulationRegulatory T-LymphocyteRoleT-CellsT-LymphocyteTGF BTGF-betaTGF-βTGFbetaTGFβTeff cellTherapeuticTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslatingTregTumor AntigensTumor-Associated Antigenautoimmune attackautoimmune conditionautoimmune destructionautoimmune disorderautoimmune pathogenesisautoimmunity diseasecancer antigenscell metabolismcellular metabaolismdevelopmentaleffector T cellhost responseimmune functionimmune system responseimmune system toleranceimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune unresponsivenessimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunological paralysisimmunoresponsemalignancymicrobial consortiamicrobial floramicrobiotamicrofloramodel of animalmucosa-associated microbesmucosa-associated microbial communitymucosa-associated microbiotamucosal floramucosal microbesmucosal microbiotamucosal microfloramultispecies consortianeoplasm/cancerpreventpreventingregulatory T-cellssocial rolethymus derived lymphocytetumor-specific antigen
Description preview
We utilize the knowledge and information acquired from studying the basic mechanisms of how the immune system interacts with mucosal microbiota, cell metabolism and apoptosis to understand the pathogeneses of autoimmune disease, chronic inflammation and cancer. We then develop more specific and effective immunotherapies to prevent and treat these…
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