grant
Immunometabolic signatures of BCG-induced neonatal trained immunity
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 6 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-4 weeks old2-ketoglutarate2-oxoglutarate21+ years oldAcetyl CoAAcetyl Coenzyme AAdultAdult HumanAdvisory CommitteesAirway infectionsAssayAttenuatedAwardBCG LiveBCG VaccineBacille Calmette Guerin vaccineBacille Calmette-GuérinBacillus Calmette Guerin VaccineBacillus Calmette GuérinBacillus Calmette-Guérin vaccineBioassayBioenergeticsBiological AssayBirthBlood PlasmaBlood SampleBlood leukocyteBlood monocyteBlood specimenBostonCause of DeathChemotactic CytokinesChildhoodChildren's HospitalCommunicable DiseasesDataDevelopmentDiseaseDisorderEnzyme AntagonistEnzyme GeneEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsEnzymesEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFundingFutureGlycolysisGoalsHealthHealth BenefitHomologous Chemotactic CytokinesHumanImmuneImmune Cell ActivationImmune ToleranceImmune memoryImmune systemImmunesImmunityImmunizationImmunizeImmunologic MemoryImmunologic ToleranceImmunological MemoryImmunologyImmunomodulationImpairmentIn VitroInfantInfectionInfection preventionInfectious DiseasesInfectious DisorderIntercrinesIntermediary MetabolismInterventionIsraelLeukocytesLeukocytes Reticuloendothelial SystemLifeLinkLipidsM bovisM tuberculosis infectionM. bovisM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMTB vaccineMarrow leukocyteMarrow monocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMediatorMedical centerMentorsMentorshipMetabolicMetabolic PathwayMetabolic ProcessesMetabolismModern ManMolecularMolecular FingerprintingMolecular ProfilingMorbidityMorbidity - disease rateMycobacterium bovisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMycobacterium tuberculosis var. bovisNIAIDNational Institute of Allergy and Infectious DiseaseNeonatalNeonatal MortalityNeonatologyNewborn InfantNewbornsParticipantParturitionPathway interactionsPediatric HospitalsPediatricsPeripheralPhenotypePlasmaPlasma SerumPrevent infectionProgram DevelopmentPublishingRandomization trialReceptor ProteinResearchRespiratory InfectionsRespiratory Tract InfectionsReticuloendothelial System, Serum, PlasmaS-acetate Coenzyme ASIS cytokinesScientistSepsisShapesShort interfering RNASmall Interfering RNAStimulusSuccinatesSystems BiologyTB infectionTB vaccineTask ForcesTechniquesTrainingTuberculosisTuberculosis VaccinesVaccinationVaccine for TBVaccine for TuberculosisVaccinesVulnerable PopulationsWhite Blood CellsWhite CellWhole BloodWorkWorld Health Organizationadaptive immunityadulthoodadvisory teamage associatedage correlatedage dependentage linkedage relatedage specificalpha ketoglutarateanamnestic reactionanti-TB vaccineattenuateattenuatescareercareer developmentchemoattractant cytokinechemokineclinical trainingcofactorcohortcytokinedeath among neonatesdeath among newbornsdeath in neonatesdeath in newborndevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldisseminated TBdisseminated tuberculosisepidemiologic investigationepidemiology studyepigeneticallyexperienceexperimentexperimental researchexperimental studyexperimentshuman modelimmune activationimmune modulationimmune regulationimmune system toleranceimmune unresponsivenessimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryin vitro Assayin vitro Modelin vivoinfection due to Mycobacterium tuberculosisinnate immune mechanismsinsightinstructormedical collegemedical schoolsmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmodel of humanmolecular profilemolecular signaturemonocytemortalitymortality among neonatesmortality among newbornsmortality in neonatesmortality in newbornsmultidisciplinaryneonatal deathneonatal demiseneonatal humanneonatal immunityneonatal morbidityneonatenewborn childnewborn childrennewborn deathnewborn morbiditynewborn mortalitynovelpathogenpathwaypediatricpreventpreventingprogramsrandomized trialreceptorresponseschool of medicinesecondary immune responsesiRNAskillstuberculosis infectiontuberculous spondyloarthropathyvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine candidates against tuberculosisvaccine developmentvaccine formulationvaccine responsevaccine responsivenessvaccine-induced responsevaccinologyvulnerable groupvulnerable individualvulnerable peoplewhite blood cellwhite blood corpuscleα-ketoglutarateα-oxoglutarateαKG
Description preview
Project Summary/Abstract
This proposal presents a 5-year research career development program focused on the study of Bacille Calmette-
Guérin (BCG) vaccine and the mechanisms of innate immune memory, otherwise known as trained immunity,
underlying its observed, pathogen-agnostic, protective health effects in early life. The candidate is currently…
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