grant

Immunologic Trajectories of Peanut Desensitization (INROADS)

Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 15 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY20260-11 years old21+ years old7S Gamma GlobulinAccidentsAcuteAddressAdultAdult HumanAffectAfter CareAfter-TreatmentAftercareAllergensAllergic ReactionAllergic to foodAllergyAllergy to foodAllergy to peanutsAntibodiesAssayBioassayBiological AssayBlood NeutrophilBlood Polymorphonuclear NeutrophilCell BodyCellsCellular AssayChildChild YouthChildren (0-21)ClinicalClinical DataClinical Treatment MoabCommunicationCommunitiesComplementComplement ProteinsDataDoseExhibitsFoodFood AllergyFood HypersensitivityGene TranscriptionGenetic TranscriptionGrantGroundnut HypersensitivityHomeHumanIgGImmuneImmune mediated therapyImmunesImmunochemical ImmunologicImmunoglobulin GImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapyIn VitroIndividualInflammatoryInnate ImmunityKnowledgeLeadLinkMachine LearningMapsMarrow NeutrophilMeasuresMediatingMedicalMiceMice MammalsModelingModern ManMolecularMonoclonal AntibodiesMurineMusNIAIDNational Institute of Allergy and Infectious DiseaseNative ImmunityNatural ImmunityNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Specific ImmunityNonspecific ImmunityOralOutcomeParticipantPatientsPb elementPeanut HypersensitivityPersonalized medical approachPhagocytosisPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePhenotypePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPrecision carePrediction of Response to TherapyPrevalenceProcessProteinsQOLQuality of lifeR-Series Research ProjectsR01 MechanismR01 ProgramRNA ExpressionReactionResearchResearch GrantsResearch Project GrantsResearch ProjectsResearch ResourcesResourcesSafetyT-CellsT-LymphocyteTechniquesTestingTh-2 CellTh2 CellsTherapeuticTranscriptTranscriptionType 2 Helper Celladaptive immunityadulthoodallergic reaction to peanutallergic response to peanutallergic to peanutsanti-IgEanti-IgEidcell assayclinical implementationclinical practicecohortcomplementationdesensitizationfood challengeglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhigh dimensionalityhomesimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedin vitro Modelindividualized approachindividualized careindividualized patient careinsightkidsmAbsmachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmonoclonal Absneutrophilnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetomalizumaboral immunotherapypeanut allergicpeanut allergyperipheral bloodpersonalization of treatmentpersonalized approachpersonalized carepersonalized medicinepersonalized patient carepersonalized therapypersonalized treatmentpharmaceuticalpost treatmentprecision approachpredict therapeutic responsepredict therapy responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprogramsresponseresponse to therapyresponse to treatmentsuccesssynergismtailored approachtherapeutic responsetherapy predictiontherapy responsethymus derived lymphocytetooltranscriptometranscriptomicstreatment predictiontreatment responsetreatment response predictiontreatment responsivenessyoungster
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SUMMARY – Overall Application: Immunologic Trajectories of Peanut Desensitization (INROADS)
Peanut allergy has tripled in prevalence in recent decades, affecting nearly 2% of adults and up to 5% of

children in some US regions. Peanut allergy is typically lifelong, can be fatal, and impacts quality of life. Our

group and others performed the…

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