grant
Immunity to Pulmonary Infections
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years oldAddressAgeAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAttenuatedAttenuated VaccinesB pertussisB. pertussisBacteriaBody TissuesBordetella pertussisCapsulesCause of DeathCell BodyCell DeathCellsCessation of lifeChildChild YouthChildren (0-21)DNA mutationDataDeathDevelopmentDoseEarly identificationElementsF tularensisF tularensis infectionF. tularensisF. tularensis infectionFrancisellaFrancisella infectionFrancisella tularensisFrancisella tularensis infectionGenerationsGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsH PertussisH. PertussisHaemophilus pertussisHistoryImageImaging technologyImmune responseImmunityImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIndividualInfectionInfection preventionInfectious AgentInflammationInflammatory ResponseInnate Immune ResponseIntermediary MetabolismK pneumoniaeK. pneumoniaeKlebsiella pneumoniaeLipid Synthesis PathwayLipidsLive-attenuated VaccineLocationLower Respiratory Tract InfectionLower respiratory infectionLungLung Respiratory SystemLung infectionsMacrophageMediatingMetabolicMetabolic ProcessesMetabolic syndromeMetabolismMitochondriaModelingMutationMφObesityOrganOutcomePasteurella tularensisPathogenesisPathway interactionsPatternPeripheralPhasePlayPopulationPrevent infectionPrimary InfectionProductionPulmonary tularemiaRecording of previous eventsReproducibilityResolutionRoleRouteSREBP control of lipid synthesisSterol regulatory element binding protein control of lipid synthesisSterol response element binding protein control of lipid synthesisStructureSurfaceT cell responseT-CellsT-LymphocyteTeff cellTissuesTularemiaVaccinationVaccinesVirulentadaptive immune responseadaptive immunityadiposityagesattenuateattenuatescapsulecell typecorpulencedevelopmentaleffector T cellgenome mutationhistorieshost responseimagingimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunization strategyimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivoinfected with F tularensisinfected with F. tularensisinfected with Francisella tularensisinfectious organisminhalation of F tularensisinhalation of F. tularensisinhalation of Francisella tularensisinsightkidslipidomicslive vaccinelive vaccineslung pathogenmetabolism measurementmetabolomicsmetabonomicsmicrobialmicroorganismmitochondrialmouse modelmultiomicsmultiple omicsmurine modelnecrocytosisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynew vaccinesnext generation therapeuticsnext generation vaccinesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynovel vaccinespanomicspathogenpathwaypneumonic tularemiaprogramsprotective efficacypulmonarypulmonary Francisella Tularensispulmonary infectionspulmonary pathogenresolutionsrespiratory tularemiaresponsesecondary infectionsocial rolethymus derived lymphocytetoolvaccination strategyyoungster
Description preview
Pulmonary infections represent 5 of the 30 most common causes of death around the world, with lower respiratory infections resulting on average of 4 million deaths each year and the leading cause of death among children under the age of 5. Despite the significance of infections in the lung we understand little about how inflammation and the…
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