grant
Immune response dynamics and hepatitis B cure in persons with and without HIV infection
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 17 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcute HepatitisAdultAdult HumanAffinityAntibodiesAntibody ResponseAntigenic DeterminantsAntigensAssayAu antigenAustralia AntigenAutologousB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellB-cell receptor repertoire sequencingB-cell receptor sequencingBCR repertoire sequencingBCR seqBCR sequencingBCRseqBindingBinding DeterminantsBioassayBiological AssayBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood SerumBlood specimenCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell FunctionCell PhysiologyCell ProcessCell Surface AntigensCellsCellular FunctionCellular PhysiologyCellular ProcessChronicChronic Hepatitis BClass II GenesClinicalClinical Treatment MoabComplexDNA mutationDevelopmentEpitopesFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesGene ExpressionGene TranscriptionGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationHBVHBV cureHBV functional cureHBV infected individualsHBV infectionHBV infection in patientsHBV infection in peopleHBV patientsHBV therapeuticHBV therapyHBV treatmentHBsAgHIVHIV InfectionsHIV and HBVHIV and hepatitis BHIV-HBVHIV/HBVHIV/hepatitis BHIV/hepatitis B virusHLA Class II GenesHTLV-III InfectionsHTLV-III-LAV InfectionsHepatitis B InfectionHepatitis B Surface AntigensHepatitis B TherapeuticHepatitis B TherapyHepatitis B TreatmentHepatitis B VirusHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImmuneImmune responseImmunesImmunocompetentImmunological Surface MarkersImmunologyIn VitroIndividualIsoformsKnowledgeLAV-HTLV-IIILabelLiverLongitudinal StudiesLymphadenopathy-Associated VirusMHC Class IIMHC Class II GenesMapsMeasurementMeasuresMediatingMetabolic MarkerMethodsMolecularMolecular InteractionMonoclonal AntibodiesMutationORFsOpen Reading FramesParticipantPersonsPhenotypePlasmaPlasma SerumProtein Coding RegionProtein IsoformsProteinsR-Series Research ProjectsR01 MechanismR01 ProgramRNA ExpressionResearch GrantsResearch Project GrantsResearch ProjectsReticuloendothelial System, Serum, PlasmaRoleSamplingSerumSortingSpecificityStaining methodStainsSubcellular ProcessSurface AntigensT cell responseT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTimeTranscriptionTranslatingViralViral DiseasesVirus DiseasesVirus-HIVadulthoodanaloganti-HBVanti-hepatitis Bantibody based detectionantibody detectionchronic HBV infectionchronic hepatitis B infectionchronic hepatitis B virus infectionchronic infections with hepatitis B viruschronically infected with HBVchronically infected with hepatitis Bcohortcytokinedetect antibodiesdevelopmentalexperienceexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygenome mutationhepatic body systemhepatic organ systemhepatitis B curehepatitis B functional curehepatitis B patientshepatitis B viral infectionhepatitis B virus and human immunodeficiency virushepatitis B virus curehepatitis B virus functional curehepatitis B virus infected individualshepatitis B virus infectionhepatitis B virus infection in patientshepatitis B virus infection in peoplehigh dimensionalityhost responseimmune competentimmune system responseimmunogenimmunoresponseimprovedin vivoindividuals with HBVindividuals with hepatitis Binfected with HBVinfected with hepatitis Binfected with hepatitis B virusinfection with HBVinfection with hepatitis B virusinnovateinnovationinnovativelong-term studylongitudinal outcome studiesmAbsmonoclonal Absneutralizing antibodyneutralizing mAbneutralizing monoclonal antibodiesnew approachesnovelnovel approachesnovel strategiesnovel strategypatients with HBVpatients with hepatitis Bpeople with HBVpeople with hepatitis Bphenotypic biomarkerphenotypic markerresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolethymus derived lymphocytetoolviral infectionvirologyvirus infectionvirus-induced disease
Description preview
Summary
This proposal aims to understand the role of hepatitis B virus (HBV)-specific B and T cell responses in cure of
hepatitis B virus, and how these responses differ in people living with HIV and chronic hepatitis B (PWHHB)
relative to people with HBV mono-infection (PWHB). To answer these questions, we will study longitudinal
blood samples…
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