grant
Immune regulation of arenavirus infections in the placenta
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Jul 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20261st trimesterAffectAnti-viral ResponseArenaviridaeArenaviridae InfectionsArenavirusArenavirus InfectionsArenavirus groupArgentine hemorrhagic fever virusArgentinian Hemorrhagic Fever VirusBlood SerumCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCaviaCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCells Placenta-TissueClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDataDeciduaDecidua GraviditasDevelopmentDiseaseDisorderDysfunctionEarly Placental PhaseExoribonucleasesExperimental ModelsFamilyFetal MortalityFetal Mortality StatisticsFetusFirst Pregnancy TrimesterFirst TrimesterFunctional disorderFutureGenetics-MutagenesisGestationGuinea PigsGuinea Pigs MammalsHarm MinimizationHarm ReductionHeterogeneityHost DefenseHost FactorHost Factor ProteinHumanIFNImmuneImmune responseImmunesImmunityImmunizationImmunochemical ImmunologicImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologicImmunologicalImmunologicallyImmunologicsImmunomodulationIn Situ HybridizationInbred StrainInfectionInflammatoryInjectionsInjuryIntegration Host FactorsInterferon Type IInterferonsIntermediary MetabolismIntracellular Communication and SignalingJuninJunin virusKnock-outKnockoutKnowledgeLCM VirusesLCMVLaboratoriesLassa fever virusLassa virusLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingLymphocytic choriomeningitis virusMammarenavirusMaternal MortalityMaternal-Fetal ExchangeMetabolic ProcessesMetabolismMethodsModelingModern ManMolecularMothersMutagenesisMutagenesis Molecular BiologyNP proteinNecrotic LesionNon-Polyadenylated RNANormal PlacentomaOutcomePathogenesisPathogenicityPatternPattern recognition receptorPhysiopathologyPichindePichinde virusPlacentaPlacenta Embryonic TissuePlacentomePre-Clinical ModelPreclinical ModelsPredispositionPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy lossPregnant WomenProductionProductivityRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqReceptor ProteinRecombinantsResistanceResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRibonucleic AcidRodentRodentiaRodents MammalsRoleSerumSignal TransductionSignal Transduction SystemsSignalingSingle cell seqSiteStrains Cell LinesSusceptibilityT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-cell therapeuticsT-cell transfer therapyTransmissionTransplacental ExposureTropismUndifferentiatedViralViral ActivityViral BurdenViral DiseasesViral FunctionViral Hemorrhagic FeversViral LoadViral Load resultViral PathogenesisViral PhysiologyVirusVirus DiseasesVirus ReplicationZoonosesZoonoticZoonotic Infectionadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyadverse pregnancy outcomebiological signal transductioncell typecomplications during pregnancycongenital infectionconstitutive expressionconstitutive gene expressioncultured cell linedevelopmentalemergent virusemerging human pathogenemerging virusexpectant motherexpectant womenexpecting motherexpecting womenexperimentexperimental researchexperimental studyexperimentsfetalhemorrhagic feverhost responsehuman pathogenimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunopathologyimmunoregulationimmunoregulatoryimmunoresponsein situ Hybridization Geneticsin situ Hybridization Staining Methodin vitro Modelindividuals who are pregnantinjuriesinnate immune pathwaysmaternal deathmaternal-fetal interfacemembermutantoffspringpathogenpathogenic viruspathogens of pandemic potentialpathophysiologypeople who are pregnantplacenta infectionplacental infectionplasma protein Zpregnancy-related complicationspregnantpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingprotein Zreceptorresearch facilityresistantsingle cell next generation sequencingsingle cell sequencingsocial roletherapeutic T-cell platformtherapeutic agent developmenttherapeutic developmentthose who are pregnanttranscriptome sequencingtranscriptomic sequencingtransmission processtrophoblasttrophoblast progenitortrophoblast progenitor celltrophoblast stem cellviral emergenceviral infectionviral multiplicationviral pathogenviral replicationviral transmissionvirus infectionvirus multiplicationvirus pathogenvirus pathogenesisvirus transmissionvirus-induced diseasewomen who are pregnant
Description preview
Project Summary.
The rodent-borne arenaviruses can cause severe hemorrhagic fevers; several of these potential pandemic
pathogens have been noted to cause high rates of maternal mortality, congenital infection, and/or fetal demise
when pregnant people are infected. The objective of this project is to determine how arenavirus infection
causes…
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