grant
Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Active ImmunizationActive vaccinationAnimal ModelAnimal Models and Related StudiesAssayAutoimmune StatusAutoimmunityB. pertussis toxinBindingBioassayBioinformaticsBiological AssayBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood VesselsBlood leukocyteBlood-Brain BarrierBody TissuesBordetella pertussis toxinBrainBrain Nervous SystemBrain StemBrainstemC perfringensC perfringens epsilon toxinC welchiiC. perfringensC. perfringens epsilon toxinC. welchiiCNS autoimmunityCandidate Disease GeneCandidate GeneCatalogsCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell Surface ReceptorsCellsCerebellumClinicalClostridium perfringensClostridium perfringens epsilon toxinClostridium welchiiConfocal MicroscopyDNA mutationDemyelinationsDiseaseDisorderDisseminated SclerosisDysfunctionEAEEncephalonEndothelial CellsEndotheliumEndotoxinsEnvironmental FactorEnvironmental Risk FactorEventExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExperimental ModelsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFore-BrainForebrainFrequenciesFunctional disorderGI microbiomeGene DeletionGene TransferGenesGenetic ChangeGenetic RiskGenetic defectGenetic mutationGoalsHemato-Encephalic BarrierHistamine-Sensitizing FactorHumanIAP Pertussis ToxinImmuneImmune infiltratesImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIndividualInflammatoryIslet-Activating ProteinKO miceKnock-out MiceKnockout MiceLesionLeukocyte TraffickingLeukocytesLeukocytes Reticuloendothelial SystemLocalized LesionLocationLymphatic cellLymphocyteLymphocyticLymphocytosis-Promoting FactorMS patientMarrow leukocyteMediatingMedulla SpinalisMeningealMessenger RNAMiceMice MammalsModelingModern ManMolecularMolecular InteractionMolecular TargetMultiple SclerosisMurineMusMutant Strains MiceMutationMyelinNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurological disabilityNon-Polyadenylated RNANull MousePathogenicityPathologyPathway interactionsPersonsPertussigenPertussis ToxinPhenotypePhysiopathologyPrevalenceProcessProsencephalonProteinsRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqReceptor ProteinRibonucleic AcidRoleSamplingSpinal CordT-CellsT-LymphocyteTechniquesTestingTimeTissuesToxinTranscriptional ControlTranscriptional RegulationWhite Blood CellsWhite CellWild Type MouseWorkadaptive immune responseadult youthautoimmune encephalomyelitisautoimmune reactivityautoreactivitybloodbrain barriercatalogcell sortingcellular targetingcentral nervous system autoimmunityclinical phenotypeclinical relevanceclinically relevantdemyelinatediagnostic tooldigestive tract microbiomeenteric microbiomeenvironmental riskflow cytophotometrygain of functiongastrointestinal microbiomegene deletion mutationgene functiongene inductiongenome mutationgut microbiomegut-associated microbiomehigh dimensionalityimmune cell infiltrateimmunopathologyinduction of genesinnovateinnovationinnovativeinsular sclerosisintestinal biomeintestinal microbiomeloss of functionloss of function mutationlymph cellmRNAmigrationmodel of animalmouse mutantmultiple sclerosis patientneuropathologicneuropathologicalneuropathologynew diagnosticsnext generation diagnosticsnovel diagnosticspathophysiologypathwaypatients with MSpatients with multiple sclerosispeople with Multiple sclerosispostcapillary venulereceptorscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic evaluationtherapeutic targettherapeutic testingthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingvascularwhite blood cellwhite blood corpusclewildtype mouseyoung adultyoung adult ageyoung adulthood
Description preview
Why some people develop Multiple Sclerosis and others do not, despite similar genetic risk and quantities of
circulating autoreactive lymphocytes, is not known. Our long-term goal is to identify environmental triggers of
MS, define the molecular and cellular basis of their action, and in doing so, propose new diagnostic tools and
therapeutic…
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