grant
Immune, hormonal, and muscle mitochondrial determinants of recovery in Acute Respiratory Distress Syndrome survivors
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldARDSActive Follow-upAcuteAcute Respiratory DistressAcute Respiratory Distress SyndromeAcute respiratory failureAdultAdult ARDSAdult HumanAdult RDSAdult Respiratory Distress SyndromeAffectAgeAgingAmericanAmino AcidsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BioenergeticsBiologicalBiological MarkersBiopsyBlood Flow CytometryBlood PlasmaBlood SerumBlood monocyteCD 120a AntigenCD120a AntigensCOVID associated ARDSCOVID associated acute respiratory distress syndromeCOVID induced ARDSCOVID induced acute respiratory distress syndromeCOVID related ARDSCOVID related acute respiratory distress syndromeCOVID survivorsCOVID-19COVID-19 associated ARDSCOVID-19 associated acute respiratory distress syndromeCOVID-19 induced ARDSCOVID-19 induced acute respiratory distress syndromeCOVID-19 infection survivorsCOVID-19 related ARDSCOVID-19 related acute respiratory distress syndromeCOVID-19 survivorsCOVID-19/ARDSCOVID-19/acute respiratory distress syndromeCOVID/ARDSCOVID/acute respiratory distress syndromeCOVID19 associated ARDSCOVID19 associated acute respiratory distress syndromeCOVID19 induced ARDSCOVID19 induced acute respiratory distress syndromeCOVID19 related ARDSCOVID19 related acute respiratory distress syndromeCOVID19/ARDSCOVID19/acute respiratory distress syndromeCV-19ClinicClinicalCohort StudiesCommunitiesConcurrent StudiesCoronavirus Infectious Disease 2019DHA SulfateDHEA SulfateDa Nang LungDataDehydroepiandrosterone SulfateDehydroisoandrosterone SulfateEndocrine Gland SecretionEnrollmentExtremitiesFutureGDF15GDF15 geneGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGoalsGrowth AgentsGrowth FactorGrowth SubstancesHPGFHealth Care CostsHealth CostsHepatocyte-Stimulating FactorHormonalHormonesHospitalsHumulin RHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImmuneImmunesImpairmentInflammationInsulinInterleukin-6InterventionLimb structureLimbsLung damageMGI-2MIC-1 gene productMIC1Macrophage Inhibitory Cytokine-1Marrow monocyteMessenger RNAMitochondriaMitochondrial MyopathiesMorphologyMulti-Ethnic Study of AtherosclerosisMuscleMuscle MitochondriaMuscle TissueMuscle WeaknessMuscular WeaknessMyeloid Differentiation-Inducing ProteinNAG-1 proteinNAG1NHLBINSAID activated gene-1 productNSAID-Activated Protein 1NSAID-Regulated Protein 1National Heart, Lung, and Blood InstituteNested Case-Control StudyNon-TrunkNonsteroidal Anti-Inflammatory Drug-Activated Protein 1Novolin ROutcomePLABPLAB ProteinPTGF-BetaPatientsPersonsPhysical FunctionPlacental Bone Morphogenic ProteinPlacental TGF-BetaPlasmaPlasma SerumPlasmacytoma Growth FactorPrasterone SulfateProcessProstate Differentiation FactorProteins Growth FactorsRandomization trialRecoveryRegular InsulinResearch PriorityReticuloendothelial System, Serum, PlasmaRoleSARS-CoV-2 associated ARDSSARS-CoV-2 associated acute respiratory distress syndromeSARS-CoV-2 induced ARDSSARS-CoV-2 induced acute respiratory distress syndromeSARS-CoV-2 related ARDSSARS-CoV-2 related acute respiratory distress syndromeSARS-CoV-2 survivorsSARS-CoV-2/ARDSSARS-CoV-2/acute respiratory distress syndromeSarcosomesSerumShock LungSkeletal MuscleSourceStiff lungSupplementationSurvivorsTNF Receptor p55TNF-sR55TNF-α receptorTNFARTNFR p60TNFR, 55-kDTNFR, 60-kDTNFR-ITNFR1TNFR55TNFR60TNFRSF1ATNFRSF1A ReceptorTNFRSF1A geneTNFalpha receptorTNFα receptorTestosteroneTherapeutic HormoneTherapeutic TestosteroneTimeTrans-TestosteroneTranscript Expression AnalysesTranscript Expression AnalysisTumor Necrosis Factor Receptor 1Tumor Necrosis Factor Receptor 55UniversitiesUniversity HospitalsVoluntary MuscleWalkingWorkactive followupadulthoodagesaminoacidanalyze gene expressionbio-markersbiobankbiologicbiologic markerbiomarkerbiorepositoryco-morbidco-morbiditycohortcomorbiditycoronavirus disease 2019coronavirus disease 2019 associated ARDScoronavirus disease 2019 associated acute respiratory distress syndromecoronavirus disease 2019 induced ARDScoronavirus disease 2019 induced acute respiratory distress syndromecoronavirus disease 2019 related ARDScoronavirus disease 2019 related acute respiratory distress syndromecoronavirus disease 2019/ARDScoronavirus disease 2019/acute respiratory distress syndromecoronavirus disease associated ARDScoronavirus disease associated acute respiratory distress syndromecoronavirus disease induced ARDScoronavirus disease induced acute respiratory distress syndromecoronavirus disease related ARDScoronavirus disease related acute respiratory distress syndromecoronavirus disease-19coronavirus disease/ARDScoronavirus disease/acute respiratory distress syndromecoronavirus infectious disease-19critical periodcytokinedisabilityenrollfollow upfollow-upfollowed upfollowupgene expression analysisgene expression assaygrowth differentiation factor 15high dimensionalityhormone deficiencyimprovedinhibitorinterestinterferon beta 2lung injurymRNAmetabolism measurementmetabolomicsmetabonomicsmitochondrialmitochondrial dysfunctionmonocytemortalitymuscle strengthmuscularnovelolder adultolder adulthoodphysical disabilityphysical impairmentphysically disabledphysically handicappedprospectivepulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrandomized trialsevere acute respiratory syndrome coronavirus 2 associated ARDSsevere acute respiratory syndrome coronavirus 2 associated acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2 induced ARDSsevere acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2 related ARDSsevere acute respiratory syndrome coronavirus 2 related acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2/ARDSsevere acute respiratory syndrome coronavirus 2/acute respiratory distress syndromesocial rolesocio-demographicssociodemographicssurvive COVID-19survive SARS-CoV-2systemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted drug trialstargeted pharmaceutical trialstargeted therapeutictargeted therapeutic agentstargeted therapytargeted therapy trialstargeted treatmenttargeted treatment trialstherapeutic targettranscriptional profilingtumor necrosis factor alpha receptortumor necrosis factor receptor 1Atumor necrosis factor α receptorvastus lateraliswet lung
Description preview
PROJECT SUMMARY
Prior to COVID-19, over 150,000 Americans survived Acute Respiratory Distress Syndrome (ARDS) each year.
To date, more than 500,000 Americans have survived COVID-19 ARDS. At least half of ARDS survivors have
persistent muscle weakness that results in increased disability, healthcare costs, and mortality. There are no
targeted…
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