grant
Immune homeostasis during Borrelia burgdorferi infection
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20267S Gamma GlobulinAb responseAbscissionAddressAffectAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibiotic TherapyAntibiotic TreatmentAntibioticsAntibodiesAntibody AffinityAntibody FormationAntibody ProductionAntibody ResponseAutoregulationAvesAvianB blood cellsB burgdorferiB cellB cellsB-CellsB-LymphocytesB-cellB. burgdorferiBacteriaBacterial InfectionsBirdsBlood SerumBody TissuesBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiCellular Immune FunctionChemicalsClinicalClinical ResearchClinical StudyDataDefectDevelopmentDiseaseDisorderDysfunctionEndotoxemiaExcisionExtirpationFailureFatty Acid Metabolism PathwayFecesFeedbackFunctional disorderFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGeneralized GrowthGenerationsGerminal CenterGrowthGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHealthHomeostasisHumanHumoral ImmunitiesHyper-γ-globulinemiaHypergammaglobulinemiaIgGImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune EvasionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune TargetingImmune responseImmune systemImmunesImmunityImmunoglobulin GImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIndividualInfectionInfection preventionInflammationInterruptionIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal LeakageIntestinal permeabilityLaboratory miceLeaky GutLife CycleLife Cycle StagesLong-Term EffectsLong-term infectionLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMacrophageMammaliaMammalsMarketingMeasuresMediatingMemoryMetabolicMethodsMiceMice MammalsMiscellaneous AntibioticModern ManMucosaMucosal TissueMucous MembraneMurineMusMφPathogenesisPatientsPersonsPhysiological HomeostasisPhysiopathologyPrevent infectionProductionRegulationRemovalResistance to antibioticsResistant to antibioticsRodentRodentiaRodents MammalsSerumShort-Chain Fatty AcidsStructure of germinal center of lymph nodeSurgical RemovalSymptomsSyndromeTestingTherapeutic InterventionTissue GrowthTissuesVector-borne diseaseVector-borne infectious diseaseVector-transmitted diseaseVector-transmitted infectious diseaseVolatile Fatty AcidsWorkadaptive immune responseadaptive immunityantibiotic drug resistanceantibiotic resistantantibody biosynthesisantibody-based immunityantigen antibody affinityautoimmune reactivityautoreactivitybacteria infectionbacterial diseasebacterial disease treatmentbacterial infectious disease treatmentchronic infectiondesigndesigningdevelopmentaldigestive tract microbiomedysbacteriosisdysbiosisdysbioticemerging pathogenenteric microbial communityenteric microbiomeenteric microbiotaexperimentexperimental researchexperimental studyexperimentsfatty acid metabolismfecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal transplantfecal transplantationgastrointestinalgastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehost responseimmune evasiveimmune functionimmune healthimmune suppressionimmune suppressive activityimmune suppressive functionimmune system healthimmune system responseimmunoglobulin biosynthesisimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinhibiting antibodyinnovateinnovationinnovativeinsightintervention therapyintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloralife courselyme spirochetemetabolomemetabonomemicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiotamicrofloramouse modelmultispecies consortiamurine modelnew pathogennovel pathogenontogenypathogenpathophysiologypersistent infectionpreventpreventingresectionresponsestooltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmenttick mediated transmissiontick populationtick transmissiontick transmittedvector-borne illnessvectorborne diseasevectorborne illnessvectorborne infectious disease
Description preview
SUMMARY
Infections can have a significant negative impact on a person’s health even long after the pathogen is cleared
from the host. Borrelia burgdorferi (Bb) the causative agent of Lyme disease causes persistent, non-resolving
infections in laboratory mice. Previous work has identified significant immune suppression in infected mice,
explaining…
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