grant
Immune determinants of pediatric HIV/SIV reservoir establishment and maintenance
NIHUS FederalResearch GrantFY20250-11 years old12-20 years oldAIDSAIDS VirusAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAdaptive Immune SystemAddressAdolescenceAnti-viral ResponseBindingBioinformatics coreBioinformatics research coreBioinformatics resource coreBloodBlood Reticuloendothelial SystemBody TissuesBone-Derived Transforming Growth FactorCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCSIFCSIF-10Cellular Immune FunctionChildChild YouthChildhoodChildren (0-21)CollaborationsCommunicationComplexCytokine Synthesis Inhibitory FactorDataDevelopmentDiseaseDisorderEnvironmentExperimental DesignsFutureGoalsHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHost FactorHost Factor ProteinHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIL-10IL10IL10AImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunesImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologyImmunomodulationIn VitroInfectionInnate Immune SystemIntegration Host FactorsInterleukin 10 PrecursorInterleukin-10InvestigationInvestigatorsKnowledgeLAV-HTLV-IIILYT3LinkLymphadenopathy-Associated VirusMaintenanceMentorsMetabolicMilk Growth FactorMissionModelingMolecular InteractionMorbidityMorbidity - disease rateNational Institutes of HealthNatureNeonatalOutputPathologyPathway interactionsPerinatal InfectionPlatelet Transforming Growth FactorPre-Clinical ModelPreclinical ModelsPrimatesPrimates MammalsResearchResearch PersonnelResearch ResourcesResearchersResourcesRoleSIVScientistSimian Immunodeficiency VirusesSystemT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTGF BTGF-betaTGF-βTGFbetaTGFβTestingThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneUnited States National Institutes of HealthViral LatencyViremiaVirusVirus LatencyVirus-HIVacquired immune systemadolescence (12-20)antiretroviral therapyantiretroviral treatmentclinical trial protocolcohortcurative interventioncurative therapeuticcurative therapycurative treatmentsdetermine efficacydevelopmentalefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperienceexperimentexperimental researchexperimental studyexperimentshigh dimensionalityimmune functionimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryin vivoinsightkidsmedical collegemedical schoolsmicrobialmortalitymultidisciplinarymultiomicsmultiple omicsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypanomicspathogenpathwaypediatricpediatric HIVpediatric departmentpediatric human immunodeficiency virusperinatal HIVperinatal periodperinatal phasepressureprogramsschool of medicinesingle cell technologysocial rolesynergismtool developmentviraemiaviral reboundviral sepsisvirus host interactionvirus reboundvirusemiayoungster
Description preview
ABSTRACT - Overall
New perinatal HIV infections continue, at a rate of about one every 3-4 minutes, 400 every day, and 3000
every week. For children living with HIV (CLWH), antiretroviral therapy (ART) greatly reduces mortality and
morbidity; however, viral rebound quickly ensues if ART is stopped. HIV persistence in a latent reservoir in
CD4+ T…
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