grant
Imaging the Pulmonary Circulation to Aid Personalized Management of Acute Respiratory Distress Syndrome
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 29 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025ARDSAcute Respiratory DistressAcute Respiratory Distress SyndromeAddressAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAffectAlveolarAnimalsAttenuatedBloodBlood PressureBlood Reticuloendothelial SystemBlood VesselsBlood VolumeBlood capillariesBlood flowBody TissuesCAT scanCO2COVID-19COVID-19 associated deathCOVID-19 associated fatalityCOVID-19 associated mortalityCOVID-19 deathCOVID-19 fatalityCOVID-19 induced deathCOVID-19 induced fatalityCOVID-19 induced mortalityCOVID-19 mortalityCOVID-19 related deathCOVID-19 related fatalityCOVID-19 related mortalityCOVID19 associated deathCOVID19 associated fatalityCOVID19 associated mortalityCOVID19 deathCOVID19 fatalityCOVID19 induced deathCOVID19 induced fatalityCOVID19 induced mortalityCOVID19 mortalityCOVID19 related deathCOVID19 related fatalityCOVID19 related mortalityCT X RayCT XrayCT imagingCT scanCV-19Carbon DioxideCarbonic AnhydrideCause of DeathCessation of lifeCharacteristicsClinicalComputed TomographyCoronavirus Infectious Disease 2019Cross-Over StudiesCrossover StudiesDa Nang LungDataDeathDorsal PositionDropsyDrug TherapyDysfunctionEdemaEndotheliumFailureFamily suidaeFunctional disorderGasesGoalsHeterogeneityHourHumanHydropsHypoxemiaImageImatinibImpairmentInflammationInflammatoryInjectionsInjuryIsolated PerfusionIsolation PerfusionIsolation Perfusion TherapyKineticsKnowledgeLifeLow Dose RadiationLungLung InflammationLung ParenchymaLung Respiratory SystemLung TissueLung damageMapsMeasuresMechanical ventilationMechanicsModern ManO elementO2 elementOutcomeOxygenPatientsPerfusionPharmacological TreatmentPharmacotherapyPhenotypePhysiologicPhysiologicalPhysiopathologyPigsPlayPneumonitisProne PositionPublishingPulmonary CirculationPulmonary EdemaPulmonary InflammationPulmonary imagingRegional PerfusionResearchResolutionRiskRoleSARS-CoV-2 associated deathSARS-CoV-2 associated fatalitySARS-CoV-2 associated mortalitySARS-CoV-2 deathSARS-CoV-2 fatalitySARS-CoV-2 induced deathSARS-CoV-2 induced fatalitySARS-CoV-2 induced mortalitySARS-CoV-2 mortalitySARS-CoV-2 related deathSARS-CoV-2 related fatalitySARS-CoV-2 related mortalitySeveritiesShock LungStiff lungStressStructure of parenchyma of lungSuidaeSupine PositionSwineTechniquesTestingTimeTissuesTomodensitometryTracerVascular DiseasesVascular DisorderVasodilatationVasodilating AgentVasodilationVasodilator AgentsVasodilator DrugsVasodilatorsVasorelaxationVisualizationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyacute careattenuateattenuatesblood perfusionblood vessel disorderbody positioncapillarycatscanclinical decision-makingclinical investigationcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycontrast CTcontrast enhancedcontrast enhanced CTcontrast enhanced computed tomographycoronavirus disease 2019coronavirus disease 2019 associated deathcoronavirus disease 2019 associated fatalitycoronavirus disease 2019 associated mortalitycoronavirus disease 2019 deathcoronavirus disease 2019 fatalitycoronavirus disease 2019 induced deathcoronavirus disease 2019 induced fatalitycoronavirus disease 2019 induced mortalitycoronavirus disease 2019 mortalitycoronavirus disease 2019 related deathcoronavirus disease 2019 related fatalitycoronavirus disease 2019 related mortalitycoronavirus disease-19coronavirus disease-19 mortalitycoronavirus infectious disease-19customized therapycustomized treatmentdata integrationdeath due to COVID-19death due to COVID19death due to SARS-CoV-2death due to coronavirus disease 2019death due to severe acute respiratory syndrome coronavirus 2death in COVIDdeath in COVID-19death in SARS-CoV-2death in coronavirus diseasedeath in coronavirus disease 2019death in severe acute respiratory syndrome coronavirus 2drug interventiondrug preservationdrug treatmentelectrical impedance tomographyfatality due to COVID-19fatality due to COVID19fatality due to SARS-CoV-2fatality due to coronavirus disease 2019fatality due to severe acute respiratory syndrome coronavirus 2high riskhypoxemiciNOimage translationimage-based methodimagingimaging approachimaging based approachimaging biomarkerimaging markerimaging methodimaging modalityimaging-based biological markerimaging-based biomarkerimaging-based markerimpaired pulmonary vascularizationimprovedin vivoindividual patientindividualized managementindividualized medicineindividualized patient managementindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinhaled nitric oxideinjuredinjuriesinstrumentlung artery blood pressurelung edemalung imaginglung injurylung scanninglung vascular diseasemechanicmechanicalmechanical respiratory assistmechanically ventilatedmortalitymortality due to COVID-19mortality due to COVID19mortality due to SARS-CoV-2mortality due to coronavirus disease 2019mortality due to severe acute respiratory syndrome coronavirus 2new approachesnon-contrast CTnoncontrast CTnoncontrast computed tomographynovel approachesnovel strategiesnovel strategypathophysiologypatient responsepatient specific responsepatient specific therapiespatient specific treatmentperfusion imagingpersonalized clinical managementpersonalized disease managementpersonalized managementpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspig modelpiglet modelporcineporcine modelprecision managementpressure in pulmonary arteriespreventpreventingpublic health relevancepulmonarypulmonary arterial blood pressurepulmonary arterial pressurepulmonary artery pressurepulmonary artery systolic pressurepulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injurypulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vasculopathyreal time monitoringrealtime monitoringregional differenceresolutionsresponseresponse to therapyresponse to treatmentresponsive patientsevere acute respiratory syndrome coronavirus 2 associated deathsevere acute respiratory syndrome coronavirus 2 associated fatalitysevere acute respiratory syndrome coronavirus 2 associated mortalitysevere acute respiratory syndrome coronavirus 2 deathsevere acute respiratory syndrome coronavirus 2 fatalitysevere acute respiratory syndrome coronavirus 2 induced deathsevere acute respiratory syndrome coronavirus 2 induced fatalitysevere acute respiratory syndrome coronavirus 2 induced mortalitysevere acute respiratory syndrome coronavirus 2 mortalitysevere acute respiratory syndrome coronavirus 2 related deathsevere acute respiratory syndrome coronavirus 2 related fatalitysevere acute respiratory syndrome coronavirus 2 related mortalitysocial rolesuidswine modeltailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsetreatment responsetreatment responsivenesstreatment strategyunique treatmentvascularvascular constrictionvascular dysfunctionvasculopathyvasoconstrictionventilationwet lung
Description preview
PROJECT SUMMARY
Acute Respiratory distress syndrome (ARDS) is a life-threatening condition caused by widespread pulmonary
inflammation leading to lung injury. ARDS has a mortality that can be higher than 40% and is the main cause of
death from COVID-19. Although necessary to support life, mechanical ventilation worsens ARDS. While
computed…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click