grant
Imaging of Neuropsychiatric Disorders with Developmental and Genetic Mechanisms
Organization NATIONAL INSTITUTE OF MENTAL HEALTHLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAffectAgreementAntipsychotic AgentsAntipsychotic DrugsAntipsychoticsAssayAutomobile DrivingAutopsyBioassayBiological AssayBiological MarkersBlood flowBrainBrain Nervous SystemCausalityCell Communication and SignalingCell SignalingCerebrovascular CirculationClinicalClinical ResearchClinical StudyCognitionCognitiveCohort StudiesConcurrent StudiesCorpus StriatumCorpus striatum structureDA NeuronDataData BasesData CollectionData SetDatabasesDevelopmentDimensionsDiseaseDisorderDopamineDopamine ReceptorDopamine neuronDrugsDysfunctionEncephalonEtiologyFoundationsFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderGWA studyGWASGene ExpressionGenerationsGenesGeneticGenetic RiskGenetic predisposing factorGenotypeGoalsHeritabilityHeterogeneityHumanHydrogen OxideHydroxytyramineImageImmediate MemoryIn vivo analysisIndividualInpatientsIntracellular Communication and SignalingIntramural ProgramIntramural Research ProgramInvestigationLinkMEG imagingMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMagnetoencephalographyMajor TranquilizersMajor Tranquilizing AgentsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMethodsModelingModern ManModern MedicineMolecularMolecular TargetMotorMsecNIMHNMR ImagingNMR TomographyNational Institute of Mental HealthNatureNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurobiologyNeurocognitiveNeurocyteNeuroleptic AgentsNeuroleptic DrugsNeurolepticsNeuronsNeurotransmittersNoiseNuclear Magnetic Resonance ImagingO elementO2 elementOutcomeOxygenPETPET ScanPET imagingPETSCANPETTParalysis AgitansParkinsonParkinson DiseasePathogenesisPatientsPersonsPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalPhysiopathologyPlacebosPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrefrontal CortexPrimary ParkinsonismProceduresProcessProtocolProtocols documentationRad.-PETReceptor ProteinRegulationReportingResearchResistanceResolutionRewardsRisk-associated variantSchizophreniaSchizophrenic DisordersSeriesSham TreatmentShapesShort-Term MemorySignal TransductionSignal Transduction SystemsSignalingStriate BodyStriatumSymptomsSystemTask PerformancesTestingTissue BanksTissue CollectionTissue repositoryTransmissionUpdateWaterWorkZeugmatographybio-markersbiologic markerbiological signal transductionbiomarkerblood flow in brainbrain blood circulationbrain blood flowbrain tissuecase controlcase-controlledcausationcerebral blood flowcerebral circulationcerebrocirculationcerebrovascular blood flowclinical careclinical effectcognitive functioncohortcollected worksdata basedata reductiondementia praecoxdevelopmentaldisease causationdopamine systemdopaminergic neurondrivingdrug withdrawaldrug/agenteffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsfMRIgenetic associationgenetic risk factorgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studyimage-based methodimagingimaging methodimaging modalityin vivo evaluationin vivo testingindexinginherited factorinnovateinnovationinnovativelongitudinal positron emission tomographymagnetoencephalogrammagnetoencephalographic imagingmillisecondmulti-modalitymultimodalitynecropsyneuralneural circuitneural circuitryneural correlateneural imagingneuro-imagingneurobiologicalneurochemicalneurochemistryneurocircuitryneurocognitive testneuroimagingneurological imagingneuronalneurophysiologicalneurophysiologyneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatrynovelpathophysiologypersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpolygenetic risk scorespolygenic risk scorepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempostsynapticpresynapticprogramsradioligandreceptorresearch facilityresistance to therapyresistantresistant to therapyresolutionsresponseresponse to therapyresponse to treatmentreward anticipationrisk allelerisk generisk genotyperisk locirisk locusrisk variantschizophrenia riskschizophrenicsham therapyspatial and temporalspatial temporalspatiotemporalstriatalsymptomatologysynaptic circuitsynaptic circuitrytheoriestherapeutic resistancetherapeutic responsetherapeutic targettherapy resistanttherapy responsetranslational geneticstransmission processtreatment resistancetreatment responsetreatment responsivenessvolunteerwhole genome association analysiswhole genome association studyworking memory
Description preview
The core aim of this project is to elucidate the nature, molecular foundations, underlying neurochemistry, and clinical correlates of neural systems-level dysfunction in schizophrenia. Recent efforts toward that end have been manifold, including studies examining pathophysiology and phenotypic heterogeneity in our patient volunteers, which have…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click