grant

Imaging Goggles for Fluorescence-Guided Surgery

Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 7 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY2026AbscissionAddressAdoptionAdvanced CancerAdvanced Malignant NeoplasmAlgorithmic SoftwareAlgorithmic ToolsAlgorithmsAnatomic SitesAnatomic structuresAnatomyAreaAstronautsAugmented RealityBody TissuesBreastBreast CancerBreast Conservation TreatmentBreast-Conserving SurgeryCalibrationCancer PatientCancerousCancersCell Communication and SignalingCell SignalingClinicalClinical EvaluationClinical ResearchClinical StudyClinical TestingComputer softwareComputersCosmonautsCuesDCISDataDepth PerceptionDetectionDevicesDiagnostic ImagingDuctal Breast Carcinoma In SituDuctal Carcinoma In SituEchographyEchotomographyEngineeringEnsureEnvironmentExcisionExtirpationEyeEyeballFeedbackFluorescenceFluorescence AgentsFluorescent AgentsFluorescent DyesFreeze SectioningFrequenciesFrozen SectionsFundingGeometryGoalsGogglesHandHeadHead and Neck CancerHead and Neck CarcinomaHead and Neck SurgeonHistologyHospitalsHumanImageImage-Guided SurgeryImaging DeviceImaging InstrumentImaging ToolInfrastructureIntracellular Communication and SignalingIntraductal CarcinomaIntraductal Carcinoma of the BreastIntuitionLeftLesionLocationLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMalignant Breast NeoplasmMalignant CellMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant TumorManuscriptsMedicalMedical UltrasoundMedical centerMethodsMicroscopeMicroscopicModern ManMonitorNASANational Aeronautics and Space AdministrationNon-Infiltrating Ductal Breast AdenocarcinomaNon-Infiltrating Ductal Carcinoma of the BreastNon-Infiltrating Intraductal AdenocarcinomaNon-Infiltrating Intraductal Breast AdenocarcinomaNon-Invasive Ductal Breast AdenocarcinomaNon-Invasive Ductal Carcinoma of the BreastNon-Invasive Intraductal Breast AdenocarcinomaNoninfiltrating Intraductal CarcinomaOperating RoomsOperative ProceduresOperative Surgical ProceduresOptical MethodsOtomyOutcomePaperPathologyPathology ReportPatient CarePatient Care DeliveryPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPositionPositioning AttributePreclinical TestingProceduresRadiographyRecurrenceRecurrentRecurrent Malignant NeoplasmRecurrent Malignant TumorRemovalReportingResearch ResourcesResearch SpecimenResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingResourcesRiskRisk ReductionRoentgenographyRuralSecond LookSecond Look SurgerySightSignal TransductionSignal Transduction SystemsSignalingSoftwareSoftware AlgorithmSpecimenStereopsisStereoscopic VisionStreamStructureSurgeonSurgicalSurgical InterventionsSurgical OncologySurgical ProcedureSurgical RemovalSurgical RevisionSurgical incisionsSurgical marginsSystemTactileTechniquesTechnologyThickThicknessTimeTissuesTrainingTumor CellUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUnited States National Aeronautics and Space AdministrationVisionVisualVisualizationWorkaspiratebiological signal transductionbreast conservation surgerybreast conserving treatmentcancer cellcancer recurrencecancer surgerycancer typecare for patientscare of patientscaring for patientsclinical testcostdesigndesigningdiagnostic ultrasoundexperiencefluorescence imagingfluorescence-guided surgeryfluorescent dye/probefluorescent imaginghandshead/neck cancerimage-based methodimagingimaging agentimaging capabilitiesimaging methodimaging modalityimaging systemimprovedincisionindustrial partnershipindustry partnerindustry partnershipinfiltrating duct carcinomainfiltrating ductal adenocarcinomainfiltrating ductal carcinomainnovateinnovationinnovativeintra-operative imagingintraoperative imagingintuitiveinvasive ductal adenocarcinomainvasive ductal carcinomalight weightlightweightmalignancymalignant breast tumormalignant head and neck tumormicroscope imagingmicroscopic imagingmicroscopy imagingmonocularmulti-modalitymultimodalityneoplasm/cancerneoplastic celloncologic surgeryoperationoperationsoptic imagingoptical imagingpatient oriented outcomespre-clinicalpre-clinical testingpreclinicalpreferenceradiological imagingreal time monitoringrealtime monitoringreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresearch clinical testingresectionrisk-reducingskillssonogramsonographysound measurementstereoscopicsuccesssurgerysurgical imagingtargeted imagingtimelinetooltumorultrasoundultrasound imagingultrasound scanninguser-friendlyvirtualvirtual worldvisual depth perceptionvisual functionwireless
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Description preview

PROJECT SUMMARY
Despite advances in pre-operative diagnostic imaging and highly skilled surgeons, the positive margin rate

(PMR) for HNC remains unacceptably high at 10-30%. Fluorescence-guided surgery (FGS) using cancer-

targeted imaging agents highlights potential cancerous areas for immediate removal, reducing the risk of

incomplete resections…

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