grant
Imaging brain fluid dynamics in relation to reactive astrogliosis and cerebral amyloid accumulation
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Dec 2004Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AD dementiaAQP4 proteinAbeta clearanceActive Follow-upAgeAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimers DementiaAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β clearanceAmyloid β-PeptideAmyloid β-ProteinAnimal ModelAnimal Models and Related StudiesAquaporinsArteriesAstrocytesAstrocytusAstrogliaAutopsyAβAβ burdenAβ clearanceBBB permeabilizationBBB permeableBlood - brain barrier anatomyBlood VesselsBlood-Brain BarrierBrainBrain Nervous SystemBrain VascularBrain imagingCardiacCerebrumClinicalCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsDataDepositDepositionDescriptorDisturbance in cognitionDysfunctionEcho-Planar ImagingEcho-Planar Magnetic Resonance ImagingEchoplanar ImagingEchoplanar Magnetic Resonance ImagingEncephalonEvaluationFrequenciesFunctional disorderFutureGoalsHeadHemato-Encephalic BarrierHumanHydrogen OxideImageImpaired cognitionImpairmentLengthLiquid substanceMAO-BMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModern ManMonoamine Oxidase BMorphologyNMR ImagingNMR TomographyNerve CellsNerve UnitNeural CellNeuritic PlaquesNeurocyteNeuronsNuclear Magnetic Resonance ImagingPETPET ScanPET imagingPETSCANPETTParticipantPathologicPathway interactionsPhysiologicPhysiologic pulsePhysiologicalPhysiopathologyPlanar Medical ImagingPlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessPulseRad.-PETRoleSenile PlaquesStudy modelsTestingTracerType B Monoamine OxidaseVentricularWaterWater Channel ProteinsWidthZeugmatographya beta peptidea-beta burdena-beta peptide clearanceabetaabeta accumulationabeta aggregationabeta burdenabeta depositionabeta peptide clearanceabnormal brain functionactive followupagesamyloid betaamyloid beta accumulationamyloid beta aggregationamyloid beta clearanceamyloid beta depositionamyloid beta peptide clearanceamyloid beta plaqueamyloid burdenamyloid β accumulationamyloid β aggregationamyloid β depositionamyloid-b plaqueamyloid-b proteinaquaporin 4arterioleastrocytic gliaastrogliosisaβ accumulationaβ aggregationaβ depositionaβ plaquesbeta amyloid burdenbeta amyloid fibrilblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain dysfunctionbrain impairmentbrain visualizationcerebralcerebral vascularcerebro-vascularcerebrovascularcognitive dysfunctioncognitive losscohortcomputer based predictioncored plaquedesigndesigningdetection sensitivitydiffuse plaquedysfunctional brainfluidfluid flowfollow upfollow-upfollowed upfollowupfootimagingimprovedin vivoinnovateinnovationinnovativeinterstitialliquidmodel of animalmonomermulti-modalitymultimodalitynecropsyneural imagingneuro-imagingneuroimagingneuroimaging biomarkerneuroimaging markerneurological imagingneuronalnovelolder adultolder adulthoodpathophysiologypathwaypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortempredictive modelingpreventpreventingprimary degenerative dementiaquantitative imagingradio frequencyradiofrequencyradiolabelradiolabelsradiotracerrespiratorysenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteintargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttemporal measurementtemporal resolutiontime measurementvascularvasomotionwater channelwater transporterβ-amyloid burdenβamyloid burden
Description preview
Project 3 Abstract
Intriguing evidence implicates reactive astrogliosis as impairing brain fluid dynamics (BFD) via multiple
mechanisms, including 1) altering expression of the aquaporin-4 (AQP-4) water channel along the astrocytic end
feet which line perivascular spaces and 2) modifying cerebrovascular vasomotion, a likely driver of perivascular…
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