grant
Imaging and theranostics to detect and promote an immune reactive tumor microenvironment
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 15 Sept 2017Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20254T1AccelerationAfter CareAfter-TreatmentAftercareB7-H1BALB C MouseBALB/cBindingBiological MarkersBiopsyBreastBreast CancerBreast Cancer ModelBreast tumor modelCD274Cancer ModelCancerModelCancersCell Communication and SignalingCell SignalingCell-Extracellular MatrixCheckpoint inhibitorChemicalsChemistryChronic DiseaseChronic IllnessCirculationClinicalCollagenComplexDevelopmentDiseaseDisorderDown-RegulationECMEngineeringEnvironmentExhibitsExtracellular MatrixExtracellular Matrix ProteinsFacultyFibrosisFundingGoalsHIF 1HIF-1 proteinHIF1HIF1 proteinHeterogeneityHypoxiaHypoxicHypoxic tumorImageImmuneImmune checkpoint inhibitorImmune infiltratesImmunesImmunocompetentInbred BALB C MiceInflammationIntracellular Communication and SignalingKPC genetically-engineered mouseKPC modelKPC mouseKPC murineLSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-CreLSL-KrasG12D/+;LSL-p53R172H/+;Pdx-1-CreLabelLiposomalLiposomesLuciferase ImmunologicLuciferasesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMiceMice MammalsModelingMolecular InteractionMultimodal ImagingMurineMusMyeloid-derived suppressor cellsNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingOxygen DeficiencyPD 1PD-1PD-1/PD-L1PD-1/PDL1PD-L1PD1PD1-PD-L1PD1/PD-L1PD1/PDL1PDL-1PETPET ScanPET imagingPETSCANPETTPancreasPancreas CancerPancreas Ductal AdenocarcinomaPancreaticPancreatic CancerPancreatic Ductal AdenocarcinomaPatientsPeptidesPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1Rad.-PETReagentReporterReportingResearchResearch ResourcesResistanceResourcesResponse ElementsServicesShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSiteSmall Interfering RNASpleenSpleen Reticuloendothelial SystemTNBCTechnologyTimeTreatment outcomeTumor OxygenationValidationZeugmatographyanti-cancer immunotherapyanticancer immunotherapybio-markersbiologic markerbiological signal transductionbiomarkercancer cellcancer immunotherapycancer microenvironmentcell killingchronic disorderdecorindeliver short interfering RNAdeliver siRNAdeliver small interfering RNAdelivery system for siRNAdelivery system for small interfering RNAdelivery vectors for siRNAdesigndesigningdevelopmentalex vivo imaginghypoxia inducible factor 1image-based methodimagingimaging agentimaging mass spectrometryimaging methodimaging modalityimaging probeimmune cell infiltrateimmune check pointimmune check point inhibitorimmune checkpointimmune competentimmune-based cancer therapiesimmunecheckpointimmunosuppressive myeloid cellsimmunotherapy for cancerimmunotherapy of cancerimproved outcomein vivoliposomal formulationliposomal preparationmalignancymalignant breast tumormammary cancer modelmammary tumor modelmass spectrometric imagingmolecular imagingmolecule imagingmulti-modal imagingmulti-modality imagingmultidisciplinarymultimodality imagingmyeloid suppressor cellsmyeloid-derived suppressive cellsnano particlenano particle deliverynano-sized particlenanoparticlenanoparticle deliverednanoparticle deliverynanosized particleneoplasm/cancernon-invasive imagingnoninvasive imagingnoveloptic imagingoptical imagingoverexpressoverexpressionpancreatic cancer modelpancreatic malignancypancreatic tumor modelpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost treatmentpre-clinicalprecision medicineprecision-based medicinepreclinicalpredict responsivenesspredicting responseprogrammed cell death 1programmed cell death ligand 1programmed cell death protein 1programmed cell death protein ligand 1programmed death 1protein death-ligand 1radiolabelradiolabelsradiotracerresistantresponseshort interfering RNA deliverysiRNAsiRNA deliverysle2small interfering RNA deliveryspatial and temporalspatial temporalspatiotemporalsuccesssuppressive myeloid cellssynergismsystemic lupus erythematosus susceptibility 2theranosticstriple-negative breast cancertriple-negative invasive breast carcinomatumortumor hypoxiatumor microenvironmentvalidations
Description preview
Our purpose in TR&D1 is to develop and validate novel translatable molecular imaging and theranostic agents
to detect and promote an immune reactive tumor microenvironment (TME) that will be integrated into the
research of multiple collaborative and service projects. Immune checkpoint inhibitors have provided some of the
most exciting treatment…
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