grant
Illuminating the Molecular Mechanisms of Replication and Transcription Coordination
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026Active SitesAddressBasal Transcription FactorBasal transcription factor genesBindingBiochemicalCancersCell NucleusChromatinClampingsClosure by clampConflictConflict (Psychology)DNADNA Polymerase IIDNA Polymerase epsilonDNA replication forkDNA-Dependent DNA Polymerase IIDataDegenerative Neurologic DisordersDeoxyribonucleic AcidDevelopmentDrosophilaDrosophila genusEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEukaryotaEukaryoteEukaryotic CellExclusionExhibitsFliesGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenome InstabilityGenomic InstabilityGenomicsGoalsIn VitroIndividualKineticsLabelLifeLightMalignant NeoplasmsMalignant TumorMeasuresMicroscopyMolecularMolecular InteractionNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-Polyadenylated RNANucleusPhotoradiationPol IIPopulationPositionPositioning AttributeProcessProteinsRNARNA ExpressionRNA Gene ProductsRegulationResearchRestRibonucleic AcidSiteSlideSystemTestingTimeTranscriptionTranscription ActivationTranscription ActivatorTranscription CoactivatorTranscription ElongationTranscription Factor CoactivatorTranscription Factor Proto-OncogeneTranscription InitiationTranscription factor genesTranscriptional ActivationTranscriptional Activator/CoactivatorWorkchromatin proteindegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalexperimentexperimental researchexperimental studyexperimentsfluorescence imagingfluorescent imagingflyfruit flyhigh definitionhigh-resolutionin vivoinhibitorinsightmalignancymolecular scaleneoplasm/cancerneurodegenerative illnesspharmacologicpreventpreventingpromoterpromotorrecruitreplication forksingle moleculespatial and temporalspatial temporalspatiotemporaltemporal measurementtemporal resolutiontime measurementtranscription factor
Description preview
Project Summary/Abstract
The goal of this proposal is to understand how replication and transcription are spatially and temporally
coordinated at molecular scales during embryonic development. A long-standing assertion is that RNA Pol II (Pol
II) is completely evicted from DNA during replication to avoid steric conflict between transcription and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click