grant
Identifying Unique Neural and Inflammatory Mechanisms of Depression in People Living with HIV
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Sept 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAddressAffectAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnteriorBiological MarkersBrainBrain Nervous SystemCatabolismChronicCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataDepressed moodDisease Frequency SurveysEmotional DepressionEmotionsEncephalonEnrollmentFunctional MRIFunctional Magnetic Resonance ImagingFutureGene TranscriptionGeneral PopulationGeneral PublicGenetic TranscriptionHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV neurocognitive impairmentHIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-associated neurocognitive disorderHTLV-III InfectionsHTLV-III-LAV InfectionsHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIndividualIndividual DifferencesInflammationInflammatoryInflammatory ResponseKnowledgeL-TryptophanLAV-HTLV-IIILevotryptophanLymphadenopathy-Associated VirusMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionModelingModern ManNMR ImagingNMR TomographyNegative ValenceNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1Nuclear Magnetic Resonance ImagingPathway interactionsPatternPeripheralPersonsPhenotypePopulationPrevalenceProtocolProtocols documentationPsychoneuroimmunologyQOLQuality of lifeRDoCRNA ExpressionResearchResearch Domain CriteriaRestRoleSpecificitySubgroupSystemTestingTranscriptionTryptophanVirus-HIVWorkZeugmatographyamygdaloid nuclear complexbio-markersbiologic markerbiomarkerbiotypesbrain abnormalitiesconnectomecytokinedepresseddepressiondepression modeldepression symptomdepressivedepressive modeldepressive symptomsdrug adherencedrug complianceemotion regulationemotional regulationenrollexperiencefMRIindexinginflammation markerinflammatory markermedication adherencemedication compliancemortalitynetwork dysfunctionneuralneural circuitneural circuitryneural imagingneural mechanismneuro-imagingneurocircuitryneuroimagingneurological imagingneuromechanismneuropathologicneuropathologicalneuropathologypathwaypotential biological markerpotential biomarkerpsychoneuroimmunologicalsadnesssocial rolesynaptic circuitsynaptic circuitry
Description preview
ABSTRACT
People living with HIV (PLWH) are particularly vulnerable to depression, which negatively
affects their quality of life, medication adherence, and even mortality. Nearly 60% of PLWH
suffer from depression, yet little is known about the underlying mechanisms of depression in
HIV. Understanding how HIV-associated chronic inflammation…
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