grant
Identifying Unique Neural and Inflammatory Mechanisms of Depression in People Living with HIV
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Sept 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAddressAffectAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnteriorBiological MarkersBrainBrain Nervous SystemCatabolismChronicCross-Sectional StudiesCross-Sectional SurveyDataDepressed moodDisease Frequency SurveysEmotional DepressionEmotionsEncephalonEnrollmentFunctional MRIFunctional Magnetic Resonance ImagingFutureGene TranscriptionGeneral PopulationGeneral PublicGenetic TranscriptionHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV disease statusHIV individualsHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV infected individualsHIV infected personsHIV infection statusHIV neurocognitive impairmentHIV peopleHIV positive individualsHIV positive peopleHIV serostatusHIV statusHIV viral infectionHIV virus infectionHIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-1 infectionHIV-associated neurocognitive disorderHIV1 infection statusHIV1 statusHumanHuman Immunodeficiency VirusesIndividualIndividual DifferencesInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammationInflammatoryInflammatory ResponseKnowledgeL-TryptophanLAV-HTLV-IIILevotryptophanLymphadenopathy-Associated VirusMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasuresMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionModelingModern ManNMR ImagingNMR TomographyNegative ValenceNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1Nuclear Magnetic Resonance ImagingPLWHPWHPathway interactionsPatternPeripheralPersonsPhenotypePopulationPrevalenceProtocolProtocols documentationPsychoneuroimmunologyQOLQuality of lifeRDoCRNA ExpressionResearchResearch Domain CriteriaRestRoleSpecificitySubgroupSystemTestingTranscriptionTryptophanVirus-HIVWorkZeugmatographyamygdaloid nuclear complexbio-markersbiologic markerbiomarkerbiotypesbrain abnormalitiesconnectomecross-sectional research studycytokinedepresseddepressiondepression modeldepression symptomdepressivedepressive modeldepressive symptomsdrug adherencedrug complianceemotion regulationemotional regulationenrollexperiencefMRIhuman immunodeficiency virus infectionindexingindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinflammation markerinflammatory markermedication adherencemedication compliancemortalitynetwork dysfunctionneuralneural circuitneural circuitryneural imagingneural mechanismneuro-imagingneurocircuitryneuroimagingneurological imagingneuromechanismneuropathologicneuropathologicalneuropathologypathwaypeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency viruspotential biological markerpotential biomarkerpsychoneuroimmunologicalsadnesssocial rolesynaptic circuitsynaptic circuitry
Description preview
ABSTRACT
People living with HIV (PLWH) are particularly vulnerable to depression, which negatively
affects their quality of life, medication adherence, and even mortality. Nearly 60% of PLWH
suffer from depression, yet little is known about the underlying mechanisms of depression in
HIV. Understanding how HIV-associated chronic inflammation…
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