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Identifying the genetic basis of strain specific antimicrobial activity against a major foodborne pathogen

Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 1 Dec 2023Deadline 31 Oct 2025 โš ๏ธ
NIHUS FederalResearch GrantFY2025AffectAgricultureAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsBacteriaBacterial InfectionsBacteriophagesBody TissuesCRISPRCRISPR/Cas systemCell BodyCellsChrysemonasClinicalClustered Regularly Interspaced Short Palindromic RepeatsCommunitiesComplexConsumptionDataDevelopmentE coliE coli InfectionsE coli O157:H7E. coliE. coli InfectionsE. coli O157:H7EngineeringEscherichia coliEscherichia coli InfectionsEscherichia coli O157:H7EvolutionFiberFlavimonasGeneticHarvestHumanInfectionInvadedMacrogolsMicrobeMiscellaneous AntibioticModern ManO157 H7O157H7P syringaeP. syringaePhagesPhenotypePlantsPolyethylene GlycolsPolyethylene OxidePolyethyleneoxidePolyoxyethylenesPrecipitationPredispositionProbioticsProductionProphylactic treatmentProphylaxisProteinsPseudomonasPseudomonas syringaeReportingResistanceS entericaS. entericaSalmonellaSalmonella entericaStructureSusceptibilitySystemTailTestingTissuesTransmissionTreatment EfficacyUnited StatesWorkanti-bacterialanti-microbialantimicrobialbacteria infectionbacterial diseasebacterial virusbacteriocincommunicable disease transmissioncommunity microbescost efficientdevelop therapydevelopmentaldisease transmissionexperimentexperimental researchexperimental studyexperimentsfood born pathogenfood borne pathogenfood-born illnessfood-borne diseasefood-borne illnessfoodborn illnessfoodborn pathogenfoodborne diseasefoodborne illnessfoodborne pathogenforward geneticshuman diseasehuman pathogeninfectious disease transmissionintervention developmentintervention efficacymembermicrobe communitymicrobial communitymicrobiomemicroorganism communitymutantnext generationnovelparticlepathogenpolymicrobial communityprecipitationspreventpreventingprophylacticresistance mechanismresistantresistant mechanismreverse geneticstherapeutic efficacytherapy developmenttherapy efficacytransmission processtreatment development

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Project Summary
Microbial communities are dynamic and are influenced by a broad suite of biotic and abiotic factors.

One of the most important factors providing structure to microbiomes are direct interactions among

members of these communities, and therefore a deeper understanding of the molecules produced by

and which affect other microbes asโ€ฆ

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Identifying the genetic basis of strain specific antimicrobial activity against a major foodborne pathogen โ€” UNIVERSITY | Dev Procure