grant
Identifying non-coding sources of mammalian craniofacial variation
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAdvisory CommitteesAffectAffinityAssayAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBase PairingBindingBioassayBiologic ModelsBiological AssayBiological ModelsBiologyBirth DefectsBody TissuesBreedingBypassCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCanine SpeciesCanis familiarisCareer CounselingCareer GuidanceCas nuclease technologyChromatinChromosome MappingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital DisordersCongenital MalformationCraniofacial AbnormalitiesDNA AlterationDNA Sequence AlterationDataDevelopmentDevelopment PlansDiseaseDisorderDistalDistantDogsDogs MammalsEducational workshopElementsEmbryoEmbryonicEnhancer ElementsEnhancersEnsureFaceFacultyFoundationsFunctional RNAFutureGWA studyGWASGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene LocalizationGene MappingGene Mapping GeneticsGene Transfer TechniquesGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic AlterationGenetic Enhancer ElementGenetsGenomeGenomicsGoalsHumanInvestigationKnowledgeLeadLeadershipLinkLinkage DisequilibriumLinkage MappingMammaliaMammalsMapsMechanicsMentorsMentorshipMethodsMiceMice MammalsModel SystemModelingModern ManMolecular InteractionMorphogenesisMorphologyMurineMusNatureNoncoding RNANontranslated RNAOccupational GuidanceOutcomePathway interactionsPb elementPhasePhenotypePlayPositionPositioning AttributeQTLQuantitative Trait LociRegulationRegulatory ElementReporter GenesResearchResearch ProposalsResearch TrainingResolutionRoleSample SizeSecureSequence AlterationShapesSkullSocial InteractionSolidSourceSpecificityStatistical MethodsTask ForcesTechnologyTestingTherapeutic InterventionTimeTissuesTotal Human and Non-Human Gene MappingTrainingTranscript Expression AnalysesTranscript Expression AnalysisTranscription Factor Proto-OncogeneTranscription factor genesTransgenesisTransgenic OrganismsTranslationsUntranslated RNAUpstream Stimulatory FactorUpstream Transcription FactorVariantVariationVocational CounselingVocational GuidanceWorkWorkshopadvisory teamallelic variantanalyze gene expressioncaninecareer counselorcareer developmentcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcomparative genomicscraniofacialcraniofacial anomaliescraniofacial defectscraniofacial developmentcraniofacial malformationcraniofaciescraniumdevelopmentaldomestic dogdrivingenhancer sequenceentire genomeexecutive coachingfacesfacialfull genomegene conservationgene expression analysisgene expression assaygene interactiongenetic architecturegenetic enhancer sequencegenetic mappinggenetic variantgenome editinggenome sequencinggenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic alterationgenomic editinggenomic variantheavy metal Pbheavy metal leadhelix-loop-helix activator USFimprovedin vivoinsightintervention therapymammalian genomemechanicmechanicalmorphogenetic processmouse genomenoncodingnovelpathwaypromoterpromotorresolutionsskillssocial influencesocial rolestatistic methodsstatistical learningtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttech developmenttechnology developmentthree dimensionaltranscription factortranscription factor MLTFtranscription factor USFtranscriptional profilingtransgenictranslationwhole genomewhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY
Facial variations play a crucial role in human identity and social interactions, with craniofacial malformations
being among the most prevalent congenital disorders. However, our understanding of the genetic factors
governing mammalian craniofacial morphogenesis is still limited. The complexity in deciphering the genetic…
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