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Identifying new strategies for prevention of cardiovascular complications of diabetes
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 May 2020Deadline 30 Apr 2026 β οΈ
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldASCVDAccelerationAdultAdult HumanAdult-Onset Diabetes MellitusApolipoproteinsApoplexyArterial Fatty StreakAssayAtherogenicityAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseBioassayBiological AssayBlood PlasmaBlood SerumBrain Vascular AccidentBrittle Diabetes MellitusCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChildChild YouthChildren (0-21)ChylomicronsComplications of Diabetes MellitusDataDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic ComplicationsDiabetic mouseER stressEventFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGlycolysisGoalsHealthHeart VascularHumanHyperglyceridemiaHypertriglyceridemiaIDDMIncidenceInsulin-Dependent Diabetes MellitusJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusLDL CholesterolLDL Cholesterol LipoproteinsLesionLinkLipoproteinsLow Density Lipoprotein CholesterolMacrophageMaturity-Onset Diabetes MellitusMethodsModern ManMyocardial InfarctMyocardial InfarctionMΟNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNormal RangeNormal ValuesPatientsPersonsPlaque InstabilityPlasmaPlasma SerumPopulationPositionPositioning AttributePrebeta-LipoproteinsPrediabetesPrediabetes syndromePrediabetic StatePredicting RiskPrevalencePreventative strategyPrevention strategyPreventive strategyProspective StudiesProteomicsRaised TGRaised triglyceridesReportingResidualResidual stateReticuloendothelial System, Serum, PlasmaRisk FactorsSerumSeveritiesSlow-Onset Diabetes MellitusStable Diabetes MellitusStrokeSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTimeTriacylglycerolTriglyceride MetabolismTriglyceridesType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesVLDLVLDL LipoproteinsVery low density lipoproteinadult onset diabetesadulthoodatheromatosisatherosclerosis plaqueatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic vascular diseasebeta-Lipoprotein Cholesterolbrain attackcardiac infarctcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcerebral vascular accidentcerebrovascular accidentcirculatory systemclinical significanceclinically significantcoronary attackcoronary infarctcoronary infarctiondiabetesdiabetes mouse modelelevated tgelevated triglycerideendoplasmic reticulum stressflow cytophotometryforecasting riskheart attackheart infarctheart infarctionhigh triglyceridesincreased triglyceridesinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabeteskidsmaturity onset diabetesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachparticleplaque vulnerabilityplaques in atherosclerosispre-diabetespre-diabeticprediabeticpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpreventpreventingrisk predictionrisk predictionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstrokedstrokestargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttreatment strategytype 2 DMtype I diabetestype II DMtype one diabetestype two diabetesunstable plaqueyounger ageyoungster
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Description preview
Currently, almost 10% of the US population (over 30 million people) suffer from type 1 or type 2 diabetes
mellitus (T1DM or T2DM) and more than 30% have pre-diabetes. Approximately 1.4 million children and adults
have T1DM. Because the prevalence of diabetes continues to rise, because both T1DM and T2DM markedly
increase the risk of cardiovascularβ¦
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