grant
Identifying Global Rejuvenation Mechanisms in Tissues that Reverses Age-Related Phenotypes in Planarians
NIHUS FederalResearch GrantFY2025AffectAgingArchitectureAutoregulationBlood Precursor CellBody TissuesBody partCell BodyCell Communication and SignalingCell SignalingCellsCytoplasmCytoplasmic GranulesDataData SetDeteriorationDiameterDiseaseDisease ProgressionDisorderElderlyEngineering / ArchitectureExhibitsExpression SignatureEyeEyeballGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionHeadHealthHematopoietic Progenitor CellsHematopoietic stem cellsHomeostasisInflammationIntracellular Communication and SignalingLinkLocationMessenger RNAMethodsMicroscopicMicroscopyMolecularMuscleMuscle TissueNatural regenerationNon-Polyadenylated RNAOocytesOrganOrgan PreservationOvaryOvocytesPatternPhenotypePhysical condensationPhysiological HomeostasisPlanariansPopulationProgenitor CellsRNARNA ExpressionRNA Gene ProductsRegenerationRejuvenationResolutionRibonucleic AcidSignal TransductionSignal Transduction SystemsSignalingStem cell pluripotencyStructureTechnologyTissue ExpansionTissuesTranscriptTranscriptionTranscriptional ControlTranscriptional RegulationWorkadult progenitoradult stem celladvanced ageage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage reversalage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging populationaging related alterationsaging related changesaging reversalaging specific alterationsaging specific changesalleviate age relatedalleviate agingalterations with ageameliorating agingbiological signal transductionblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcell typechanges with agecondensationcounter age relatedcounter agingcounteract age relatedcounteract agingdifferential expressiondifferentially expressedfrailtygene expression patterngene expression signaturegeriatricglobal gene expressionglobal transcription profilegranulehematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellimprovedinsightmRNAmetermultiomicsmultiple omicsmuscularpanomicspluripotencypluripotent statepopulation agingprogenitor cell functionprogenitor functionregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueregeneration based therapyregeneration functionregeneration therapyregenerativeregenerative functionregenerative functionalityregenerative therapeuticsregenerative therapyresolutionsreverse agereverse agingreverse aging effectsreversible agingsenior citizensomatic progenitorsomatic stem cellspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicsstem and progenitor cell functionstem and progenitor functionstem cell functionstem cellssuper high resolutionsuperresolutiontissue regenerationtissue regrowthtissue renewaltissue specific regenerationtranscriptional differencestranscriptional profiletranscriptional signaturetranscriptometranscriptomicsultra high resolution
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PROJECT SUMMARY/ABSTRACT
The preservation of organ functions, such as eyesight and mobility, is a significant health concern in the elderly
population. Organ frailty and disease progression are associated with the dysregulation of tissue homeostasis,
which is typically regulated by regenerative units, consisting of adult stem cells (ASCs) and…
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