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Identifying Determinants of Borrelia burgdorferi and Peromyscus leucopus symbiosis
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 1 Aug 2023Deadline 2 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025Active Follow-upAcuteAffectAmericanAssayB burgdorferiB. burgdorferiBacteriaBacterial GenesBioassayBiological AssayBionomicsBlack-legged TickBody TissuesBorreliaBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCanine SpeciesCanis familiarisCas nuclease technologyCell BodyCell LineCellLineCellsCharacteristicsChronicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDataData SetDeer TickDefectDevelopmentDogsDogs MammalsEcologyElementsEnabling FactorsExperimental DesignsFibroblastsFoundationsFrequenciesFutureGene ExpressionGenesGeneticGenetic ScreeningGleanGoalsGrantHealthHistologyHistopathologyHouse miceHumanI scapularisI. scapularisImmune responseImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIn VitroInbreedingInfectionInflammationInstitutionIx scalpularisIx. scapularisIxodes damminiIxodes scapularisIxodidaKineticsKnock-outKnockoutLaboratoriesLeadLeftLibrariesLongitudinal StudiesLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMacrophageMiceMice MammalsMicroscopicModern ManMolecularMonitorMurineMusMus musculusMφNaturePaperPathologyPathway interactionsPatientsPb elementPeromyscusPostdocPostdoctoral FellowPublic HealthPublicationsPublishingRNA SeqRNA sequencingRNAseqReagentResearchResearch AssociateRodentRodent ModelRodentiaRodents MammalsScientific PublicationSeriesSideSignal PathwaySkinStrains Cell LinesSymbiosisSymptomsTechniquesTestingTicksTimeTissuesTn-seqTnseqTrainingTransmissionUnited StatesWorkactive followupblacklegged tickborrelialcaninecommensalismcostcultured cell linecytokinedata integrationddPCRdevelopmentaldomestic dogdroplet digital PCRdroplet digital Polymerase Chain Reactiondroplet-based digital PCRenzooticexperienceexperimentexperimental researchexperimental studyexperimentsfeedingfollow upfollow-upfollowed upfollowupgenome scalegenome-widegenomewidegenomic toolsgraduate schoolhealth goalsheavy metal Pbheavy metal leadhost microbe associationhost microbe relationshiphost responsehost-microbe interactionshost-microbial interactionshost-microorganism interactionshuman pathogenimmune system responseimmunoresponseimprovedin vivoinsightlong-term studylongitudinal outcome studieslyme spirochetemouse modelmurine modelmutantnovelpathogenpathwaypost-docpost-doctoralpost-doctoral traineepost-doctoral trainingpreventpreventingprogramsresearch associatesresponsescreeningscreeningsskillstooltraining opportunitytranscriptome sequencingtranscriptomic sequencingtransmission processtransposon insertion sequencingtransposon sequencingvector tick
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Description preview
Project Summary/Abstract:
My postdoctoral studies focus on understanding how Borrelia burgdorferi, the causal agent of Lyme disease,
survives in nature—which involves studying its relationship with its natural mammalian reservoir host,
Peromyscus leucopus. While previous work has demonstrated that Ixodes scapularis ticks disproportionately
obtain…
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