grant
Identifying Convergent Circuit Disruptions Across Genetically-Distinct Models of Autism
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 22 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ASDAcoustic Perceptual DisorderAddressAffectAmmon HornAnimalsAntibiotic AgentsAntibiotic DrugsAntibioticsAssayAuditoryAuditory Comprehension DisorderAuditory CortexAuditory PerceptionAuditory Perceptual DiseasesAuditory Perceptual DisordersAuditory Processing DisorderAuditory areaAuditory systemAutismAutistic DisorderBehaviorBehavioralBehavioral SymptomsBioassayBiologic ModelsBiological AssayBiological ModelsBourneville DiseaseBourneville PhakomatosisBourneville syndromeBourneville-Brissaud diseaseBourneville-Pringle syndromeBrainBrain Nervous SystemCell Communication and SignalingCell SignalingClinicalClinical TrialsCommon Rat StrainsComplexConnector NeuronCornu AmmonisDNA mutationDevelopmentDisablingDiseaseDisorderDrug TherapyDysfunctionEarly Infantile AutismElectrophysiologyElectrophysiology (science)EncephalonEpiloiaEquilibriumEscalante syndromeExhibitsExtracellular Matrix ProteinsFDA approvedFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FoundationsFragile XFragile X SyndromeFunctional disorderGeneticGenetic ChangeGenetic defectGenetic mutationHippocampusHuman GeneticsHypersensitivityImpairmentInfantile AutismIntercalary NeuronIntercalated NeuronsInterneuron functionInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingKanner's SyndromeLabelLeadLinkMapsMartin-Bell SyndromeMartin-Bell-Renpenning syndromeMechanistic Target of RapamycinMemoryMetabolicMiceMice MammalsMinocyclineMiscellaneous AntibioticModel SystemModelingMolecularMolecular FingerprintingMolecular ProfilingMurineMusMutationNatureNerve CellsNerve UnitNeural CellNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurocognitiveNeurocyteNeuronal DysfunctionNeuronsNeurophysiology / ElectrophysiologyParvalbuminsPathogenesisPathway interactionsPb elementPharmacological TreatmentPharmacotherapyPhenotypePhysiologicPhysiologicalPhysiopathologyPringle diseaseProtein BiosynthesisPsychoacoustical DisordersRAFT1RatRats MammalsRattusRecurrenceRecurrentRenpenning syndrome 2ResearchRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRisk FactorsRodent ModelSclerosisSensorySensory impairmentSignal TransductionSignal Transduction SystemsSignalingSocial BehaviorSymptomsSynapsesSynapticTechniquesTestingTrainingTuberous SclerosisX-linked mental deficiency-megalotestes syndromeX-linked mental retardation with fragile X syndromeX-linked mental retardation-fragile site 1 syndromeadenoma sebaceumauditory processingautism attributesautism indicatorautism modelautism spectral disorderautism spectrum disorderautism spectrum disorder featuresautism spectrum disorder indicatorautism spectrum disorder symptomsautism symptomologyautism symptomsautism-fragile X (AFRAX) syndromeautism-like symptomsautism-related attributesautistic featuresautistic spectrum disorderautistic symptomsautistic traitsautistic-like symptomsbalancebalance functionbehavior phenotypebehavioral phenotypingbiological signal transductioncell typecentral processing disordercerebral sclerosiscommunication behaviordensitydevelopmentaldrug interventiondrug treatmentelectrophysiologicalepiploiafra(X) syndromefra(X)(28) syndromefra(X)(q27) syndromefra(X)(q27-28) syndromefragile X-mental retardation syndromefragile Xq syndromefragile site mental retardation 1genome mutationhearing perceptionheavy metal Pbheavy metal leadhereditary multiple system hamartomatosishippocampalin vivoinformation processinginnovateinnovationinnovativelenslensesmTORmacro-orchidism-marker X (MOMX) syndromemacro-orchidism-marker X syndromemammalian target of rapamycinmar(X) syndromemarker X syndromemental retardation-macroorchidism syndromemodel of autism spectrum disordermolecular profilemolecular signaturemouse modelmurine modelmutantneural circuitneural circuitryneural dysfunctionneurinomatosis centralisneurocircuitryneuromatosis universalisneuronalneurophysiologicalneurophysiologyneuropsychiatricneuropsychiatryneurospongioblastosis diffusanew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoptogeneticspathophysiologypathwayphacomatosispharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingprogramsprotein synthesissclerosis tuberosasensory systemskillssociobehaviorsociobehavioralsoundsound perceptionspongioblastosis circumscriptasynapsesynapse inhibitionsynaptic circuitsynaptic circuitrysynaptic inhibitiontooltreatment strategytuberose sclerosistuberous sclerosis complex
Description preview
Identifying Convergent Circuit Disruptions Across Genetically-Distinct Rat Models of ASD
Summary: Recent advances from human genetic and animal studies have greatly increased our
understanding of the molecular and cellular basis of autism spectrum disorders (ASD). Connecting these risk
factors to clinical symptoms in autism remains a significant…
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