grant
Identifying and Targeting Autoantigen Specific B cells in ANCA Vasculitis
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025ANCA associated vasculitisANCA vasculitisAcute B-Lymphocytic LeukemiaAdvisory CommitteesAngiitisAnti-Rejection TherapyAnti-neutrophil cytoplasmic antibody associated vasculitisAnti-neutrophil cytoplasmic antibody related vasculitisAnti-neutrophil cytoplasmic antibody vasculitisAnti-neutrophil cytoplasmic antigen induced vasculitisAnti-neutrophil cytoplasmic autoantibody associated vasculitisAnti-neutrophil cytoplasmic autoantibody vasculitisAntibodiesAntibody ResponseAntibody SuppressionAntigensAssayAutoantibodiesAutoantigensAutoimmune DiseasesAutologous AntigensB blood cellsB cellB cell depletion therapyB cell directed therapyB cell progenitor acute lymphoblastic leukemiaB cell targeted therapyB cell therapiesB cell therapyB cellsB-ALLB-Cell Acute Lymphocytic LeukemiaB-Cell Acute Lymphoblastic LeukemiaB-Cell Antigen CD22B-Cell DevelopmentB-Cell Lymphoblastic LeukemiaB-CellsB-LymphocytesB-cellB-cell ALLB-cell precursor acute lymphoblastic leukemiaB3 antigenBasic ResearchBasic ScienceBioassayBiological AssayBlood NeutrophilBlood Polymorphonuclear NeutrophilCD22CD22 antigenCD22 geneCancersCaringCell BodyCell FunctionCell LineCell PhysiologyCell ProcessCell secretionCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCellular SecretionClinicClinicalClinical DataClinical EvaluationClinical TestingCollectionCommunicationCytoplasmDNADataData AnalysesData AnalysisDedicationsDeoxyribonucleic AcidDevelopmentDevelopment PlansDiseaseDisease remissionDisorderEducational workshopEnrollmentEnvironmentExhibitsFacultyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFormulationFutureGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGerm LinesGoalsIRBIRBsImmune MarkersImmunityImmunochemical ImmunologicImmunogeneticsImmunogenomicsImmunologicImmunologic MarkersImmunologic SubtypingImmunologicalImmunologicallyImmunologicsImmunologyImmunomodulationImmunophenotypingImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosuppressive TherapyInfectionInstitutional Review BoardsInstructionInternationalInvestigatorsKidneyKidney Urinary SystemKnowledgeLeadershipLifeLigand BindingLigandsLiposomalLiposomesMaintenanceMalignant NeoplasmsMalignant TumorMarrow NeutrophilMemory B CellMemory B-LymphocyteMentorsMentorshipMethodologyMethodsMonitorNeutrophilic GranulocyteNeutrophilic LeukocyteNorth CarolinaOutcomePathogenicityPatient CarePatient Care DeliveryPatient RecruitmentsPatientsPhysiciansPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPre-B-Cell LeukemiaPrecursor B Lymphoblastic LeukemiaProductionProductivityProspective cohortRNA SequencesReceptor ProteinRecurrenceRecurrentRecurrent diseaseRegistriesRelapseRelapsed DiseaseRemissionResearchResearch PersonnelResearch ResourcesResearch TrainingResearchersResourcesRiskSIGLEC2SamplingScientistSelf-AntigensSialic Acid-Binding Immunoglobulin-Like Lectin 2Single cell seqStrains Cell LinesSubcellular ProcessSurfaceTask ForcesTestingTherapeutic immunosuppressionTrainingTraining ActivityTranscript Expression AnalysesTranscript Expression AnalysisTranslatingTranslational ResearchTranslational ScienceUniversitiesVaccinesVasculitisWorkWorkshopadaptive immune responseadvisory teamanalyze gene expressionartificial immunosuppressionautoimmune antibodyautoimmune conditionautoimmune disorderautoimmune kidney diseaseautoimmune kidney injuryautoimmune renal diseaseautoimmune renal injuryautoimmunity diseaseautoreactive antibodybiomarker identificationcare for patientscare of patientscareercareer developmentcaring for patientscell immortalizationclinical remissionclinical testcohortconferenceconventioncultured cell linedata interpretationdesigndesigningdevelop therapydevelopmentaldisease modeldisorder modeldrug developmentempowermentenrollexperienceexperimentexperimental researchexperimental studyexperimentsfightingflow cytophotometrygene expression analysisgene expression assayhypogammaglobulinemiaidentification of biomarkersidentification of new biomarkersimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune-based biomarkersimmunogenimmunologic reactivity controlimmunological biomarkersimmunological markersimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppression therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vitro Assayinnovateinnovationinnovativeinsightinterestintervention developmentmalignancymarker identificationmedical collegemedical schoolsmeetingmeetingsnano particlenano-sized particlenanoparticlenanoparticle drugnanoparticle therapynanosized particleneoplasm/cancerneutrophilnovelparticipant recruitmentpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespre-clinical studypreclinical studyprofessorreceptorrenalresearch clinical testingrisk minimizationschool of medicineself reactive antibodyside effectsingle cell next generation sequencingsingle cell sequencingsummitsymposiasymposiumtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic nanoparticlestherapy developmenttooltraining moduletranscriptional profilingtranscriptomicstranslation researchtranslational investigationtreatment developmentvasculitides
Description preview
PROJECT SUMMARY
I am an Assistant Professor at the University of North Carolina-Chapel Hill (UNC) School of Medicine and part
of the UNC Kidney Center. I am a clinician and researcher taking care of patients with autoimmune kidney
diseases with a specific interest in antineutrophil cytoplasmic autoantibody (ANCA) vasculitis. The current
treatment…
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