grant
Identification of Regulatory Mechanisms Operating in Rare Pathogenic Astrocyte Subsets in Multiple Sclerosis with a Novel Genomic Technology
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AddressAlternate SplicingAlternative RNA SplicingAlternative SplicingAstrocytesAstrocytusAstrogliaAtlasesBasal Transcription FactorBasal transcription factor genesBiological MarkersBiologyCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Communication and SignalingCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCellsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCytometryDNADNA MarkersDNA biomarkersDNA mutationDeoxyribonucleic AcidDiseaseDisorderDisseminated SclerosisEAEExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExpression SignatureGene Expression ProfileGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGrantHumanIntracellular Communication and SignalingInvestigationKO miceKnock-out MiceKnockout MiceLinkMethodsMiceMice MammalsModern ManMultiple SclerosisMurineMusMutationNCOR2NCOR2 geneNR3C2NR3C2 geneNerve DegenerationNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNeuron DegenerationNon-Polyadenylated RNANuclear ReceptorsNucleic AcidsNull MousePathogenesisPathogenicityPathologyPhysiologicPhysiologicalPopulationPre-Clinical ModelPreclinical ModelsPrionsRNARNA Gene ProductsRNA SeqRNA SplicingRNA markerRNA sequencingRNAseqReceptor SignalingReportingRibonucleic AcidRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSplicingSurfaceTRAC-1TRAC1TechnologyTherapeutically TargetableTranscriptTranscription ActivationTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationVirus IntegrationXBP1XBP1 geneastrocytic gliaautoimmune encephalomyelitisbio-markersbiologic markerbiological signal transductionbiomarkerbrain cellcell sortingcell typeco-repressorconditional knock-outconditional knockoutcorepressordetection methoddetection proceduredetection techniquedisease controldisorder controlepigenomicsgene co-repressorgene corepressorgene expression patterngene expression signaturegenetic co-repressorgenetic corepressorgenome mutationin vivoinsular sclerosisinterestknock-downknockdownmouse modelmurine modelneural degenerationneurodegenerationneurodegenerativeneurological degenerationneurological diseaseneuronal degenerationnovelposttranscriptionalpre-clinicalpreclinicalresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell technologysingle cell transcriptomic profilingsingle moleculesingle-cell RNA sequencingsocial roletranscription factortranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranscriptomicsviral genome integrationviral integrationvirus genome integration
Description preview
ABSTRACT
Single-cell genomic, epigenomic, and transcriptomic technologies can identify unique cell subsets with important
physiologic roles; however, RNA or DNA signatures cannot always be linked to unique surface markers,
hampering the re-isolation of these cell subsets for in-depth analyses. Moreover, conventional single-cell
methods require…
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