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Identification of Novel Regulatory Mechanisms Driving Human beta-Cell Maturation and Function.
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldATAC sequencingATAC-seqATACseqAdolescentAdolescent YouthAdultAdult HumanAffectAgeAmericanAssayAssay for Transposase-Accessible Chromatin using sequencingAutoimmune DiseasesAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBeta CellBioassayBiological AssayBlood GlucoseBlood SugarBlood VesselsBrittle Diabetes MellitusCRISPR activationCRISPR activatorCRISPR approachCRISPR based activationCRISPR based approachCRISPR gene activationCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR transcription activationCRISPR transcriptional activationCRISPR-CAS-9CRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS approachCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCUT&RUNCas nuclease technologyCell BodyCell DifferentiationCell Differentiation processCell FunctionCell MaturationCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexD-GlucoseDataDextroseElectroporationElementsEnhancer ElementsEnhancersEvaluationFunctional RNAGene ActivationGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic Enhancer ElementGenetic TranscriptionGlucoseGoalsHumanHumulin RHypoglycemiaIDDMImpairmentInsulinInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusIslet CellJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLinkMeasuresMiceMice MammalsModern ManMurineMusNR2B3Natural regenerationNoncoding RNANontranslated RNANovolin RPancreatic beta CellPancreatic β-CellPathway interactionsPersonsPostdocPostdoctoral FellowProgenitor CellsRNA ExpressionRNA SeqRNA sequencingRNAseqRXRCRXRGRXRG geneRegenerationRegenerative MedicineRegular InsulinRegulatory ElementResearch AssociateRibonucleoproteinsRiskRoleSchemeSourceStructure of beta Cell of isletSubcellular ProcessSudden-Onset Diabetes MellitusSystemT1 DMT1 diabetesT1DT1DMTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUntranslated RNAactivating CRISPR technologyadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagesassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingautoimmune conditionautoimmune disorderautoimmunity diseasecell regenerationcellular differentiationcellular regenerationdrivingdruggable targetelectroporative deliveryenhancer sequencegene electrotransfergene manipulationgenetic enhancer sequencegenetic manipulationgenetically manipulategenetically perturbhuman progenitor cell derivedhuman stem cell-derivedhypoglycemichypoglycemic episodesindexinginsulin dependent diabetesinsulin dependent type 1insulin secretionisletjuvenilejuvenile diabetesjuvenile diabetes mellitusjuvenile humanketosis prone diabetesknock-downknockdownmacrovascular complicationmacrovascular diseasemanufacturenew technologynoncodingnovelnovel technologiespancreas beta cellpancreas β cellpancreatic b-cellpathwaypost-docpost-doctoralpost-doctoral traineepreventpreventingpromoterpromotorregenerateresearch associatesshRNAshort hairpin RNAsmall hairpin RNAsocial rolestandard carestandard treatmentstem cellstooltranscription factortranscriptome sequencingtranscriptomic sequencingtype I diabetestype one diabetesvascularβ-cellβ-cellsβCell
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Abstract
Type 1 Diabetes mellitus (T1D) is an autoimmune disease targeting pancreatic β-cells that affects over 8 million
people worldwide. Standard treatment for T1D is limited to administration of exogenous insulin, which can result
in hypoglycemic episodes, and fails to fully prevent micro- and macro- vascular complications. Thus, deriving…
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