grant
Identification of novel lead EphB1/2 tyrosine kinase inhibitors targeting peripheral neuropathic pain
Organization TEXAS TECH UNIVERSITY HEALTH SCIS CENTERLocation LUBBOCK, UNITED STATESPosted 1 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY20262-hydroxyphenylalanine2-tyrosineAcuteAddressAmerican Medical AssociationAntibiotic AgentsAntibiotic DrugsAntibioticsAnxietyAnzataxAsotaxBehaviorBehavioralBindingBiological MarkersBrainBrain Nervous SystemBristaxolCNS Nervous SystemCatalytic CoreCatalytic DomainCatalytic RegionCatalytic SiteCatalytic SubunitCell Communication and SignalingCell SignalingCentral Nervous SystemCessation of lifeComplexCrystallizationDeathDevelopmentDorsal Horn CellsDorsal Horn NeuronsDorsal Horn of the Spinal CordDorsal Root GangliaDoseDrug KineticsDrug Synthesis and ChemistryEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEncephalonEph Receptor LigandsEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorEphrinsEpidemicEventFBJ Murine Osteosarcoma Viral Oncogene HomologFBJ osteosarcoma oncogeneFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFOS Family ProteinFOS ProteinFOS geneFamily memberFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsG0S7Gene ExpressionGenerationsGoalsHalf-LifeHeterozygoteImmediate-Early GenesImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn VitroInflammationInflammatoryInjuryIntracellular Communication and SignalingKO miceKinasesKnock-out MiceKnockout MiceLeadLigandsMaintenanceMeasuresMediatingMedulla SpinalisMiceMice MammalsMinocyclineMiscellaneous AntibioticMolecularMolecular InteractionMurineMusN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNMDA Receptor-Ionophore ComplexNMDA ReceptorsNerveNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeuraxisNeurobiologyNeurocyteNeuronal TransmissionNeuronsNociceptionNull MouseOpiatesOpioidPNS DiseasesPTK InhibitorsPTK ReceptorsPaclitaxelPaclitaxel (Taxol)PainPainfulPathologicPathway interactionsPb elementPerceptionPeripheralPeripheral Nerve DiseasesPeripheral Nervous SystemPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPermeabilityPharmacokineticsPhosphotransferase GenePhosphotransferasesPosterior Horn CellsPosterior Horn NeuronsPraxelProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProtein Tyrosine Kinase InhibitorsProtooncogene FOSReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneReportingRodent ModelRoleSignal TransductionSignal Transduction SystemsSignalingSpinal CordSpinal GangliaSpinal cord posterior hornStimulusStructureSynapsesSynapticTK InhibitorsTaxolTaxol ATaxol KonzentratTetracyclinesThermal HyperalgesiasTransmembrane Receptor Protein Tyrosine KinaseTransphosphorylasesTyrosine KinaseTyrosine Kinase InhibitorTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseUnited StatesWestern BlottingWestern Immunoblottingallodyniaanalogaxon signalingaxon-glial signalingaxonal signalingbehavior studybehavioral studybio-markersbiologic markerbiological signal transductionbiomarkerc fosc-fos Genec-fos Proteinc-fos Proto-Oncogenescentral sensitizationchronic constriction injurychronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentconstrictiondevelopmentaldorsal root gangliondrug synthesisexperimentexperimental researchexperimental studyexperimentsglia signalingglial signalingheavy metal Pbheavy metal leadheterozygosityhydroxyaryl protein kinasein vivoinflammatory paininhibitorinjurieskinase inhibitorlicit opioidmechanical allodyniamultidisciplinarynerve damagenerve signalingneural signalingneurobiologicalneuronalneuronal signalingneuropathic painneurotransmissionnext generationnociceptivenon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicsnovelopiate medicationopiate overdoseopiate related overdoseopioid drug overdoseopioid induced overdoseopioid intoxicationopioid medicationopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid toxicityortho-tyrosinepain behaviorpain modelpain processingpainful neuropathypathwaypharmacologicpre-clinicalpreclinicalprescribed opiateprescribed opioidprescription opiateprescription opioidprotein blottingreceptorscaffoldscaffoldingsciatic nervesciatic nerve injurysmall moleculesocial rolesynapsesynergismtooltreat chronic paintyrosyl protein kinasev-FOS FBJ Murine Osteosarcoma Viral Oncogene Homologvalidation studies
Description preview
PROJECT SUMMARY/ ABSTRACT.
Chronic pain is a common debilitating condition that often leads to the prescription of escalating opioid doses
and has created a nationwide severe crisis. In September 2022, the American Medical Association issued a
report entitled "Nation's opioid-related overdose and death epidemic continues to worsen," which stated…
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