grant
Identification of human gut microbe-derived xenolipids: impact of fibers and host metabolic health
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AcidsAcuteAddressAdipocytesAdipose CellAdipose tissueAdult-Onset Diabetes MellitusAgeAnimal ModelAnimal Models and Related StudiesAnimalsAntiinflammatory EffectAutomobile DrivingBacteriaBindingBloodBlood Reticuloendothelial SystemBody TissuesCFA synthaseCarbohydratesCatalogingCatalogsCausalityCell Communication and SignalingCell SignalingChIP SequencingChIP-seqChIPseqCharacteristicsChemicalsCommon Rat StrainsCommunicationCommunitiesComplexDNA seqDNA sequencingDNAseqDataDiabetes MellitusDietDietary ComponentDietary FactorsDiseaseDisease remissionDisorderDisparateEndocrine systemEndocrine/Metabolic Organ SystemEtiologyExerciseFat CellsFatsFatty AcidsFatty TissueFatty acid glycerol estersFecesFiberG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGI microbiotaGPCRGastrointestinal microbiotaGeneral TaxonomyGenerationsGoalsHealthHealth StatusHepatic CellsHepatic Parenchymal CellHepatocyteHormonal SystemHumanImmune systemInflammationIntermediary MetabolismIntestinalIntestinesIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKnowledgeLabelLeadLevel of HealthLibrariesLinkLipidsLipocytesLiteratureLiver CellsMacrophageMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMetabolicMetabolic ProcessesMetabolic/Endocrine Body SystemMetabolismMicrobeModern ManModificationMolecularMolecular InteractionMφNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNuclear ReceptorsNutraceuticalObesityOrganoidsOutcomePPARPPAR alphaPPAR deltaPPAR gammaPPAR-gPPAR-αPPAR-γPPAR-δPPARD proteinPPARalphaPPARdeltaPPARgammaPPARαPPARγPPARδPathway interactionsPatternPb elementPeroxisome Proliferative Activated Receptor GammaPeroxisome Proliferator-Activated Receptor alphaPeroxisome Proliferator-Activated Receptor deltaPeroxisome Proliferator-Activated Receptor gammaPeroxisome Proliferator-Activated Receptor αPeroxisome Proliferator-Activated Receptor γPeroxisome Proliferator-Activated Receptor δPeroxisome Proliferator-Activated ReceptorsPersonsPhenotypePhylogenyPhysiologicPhysiologicalPhysiologyPlayPopulationProbioticsProductionPublishingRNA SeqRNA sequencingRNAseqRatRats MammalsRattusRegulationRemissionReproducibilityResearchRoleSame-sexSamplingShapesSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStructureSystemT2 DMT2DT2DMTaxonomyTechnologyTestingThiazolidinedione ReceptorTimeTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnsaturated Fatty Acidsadiposeadiposityadult onset diabetesagesanti-inflammatory effectbacteria in the gutbacterial communitybiological signal transductionbowelcarbenecatalogcausationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcommunity microbescorpulencecyclopropanecyclopropane fatty acid synthasecyclopropane synthetasediabetesdietsdisease causationdrivingendocrine gland/systementeric microbial communityenteric microbiotafield based datafield learningfield studyfield testfitnessfunctional outcomesgastrointestinal microbial floragut bacteriagut communitygut floragut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiotagut microbioticgut microflorahealth levelheavy metal Pbheavy metal leadhuman modelinnovateinnovationinnovativeintestinal floraintestinal microbesintestinal microbiotaintestinal microfloraintestinal tract microfloraketosis resistant diabeteslipidomematurity onset diabetesmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmethylenemicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramicroorganism communitymodel of animalmodel of humanmultispecies consortianovelpathwaypolymicrobial communityprebioticsresponsescreeningscreeningssocial rolestemstooltooltraffickingtranscriptome sequencingtranscriptomic sequencingtrimethylenetype 2 DMtype II DMtype two diabeteswhite adipose tissueyellow adipose tissue
Description preview
Project Summary: The nexus between diet, microbiome, and host involves molecular signals and xenometabolites (“non-
self” molecules derived from microbial metabolism) that remain largely unmapped. DNA and RNA sequencing
technologies have led to major advancements in understanding how abundances of specific gut microbes correlate to
health, diet,…
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