grant
Identification of Covalent Transcriptional Dependencies in Melanoma
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 14 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAffinityAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsApplications GrantsBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBiochemicalBiologic ModelsBiologicalBiological ModelsBiotinCancer DrugCancer GenesCancer ModelCancer TreatmentCancer-Promoting GeneCancerModelCancersCell BodyCell LineCellLineCellsChIP SequencingChIP-seqChIPseqCharacteristicsChemicalsCombining SiteComplexCysteineDNA BindingDNA Binding InteractionDNA boundDNA mutationDependenceDerivationDerivation procedureDevelopmentDrug TargetingDrug TherapyDrugsElementsEnzyme GeneEnzymesFoundationsFutureGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGluesGoalsGrant ProposalsGrowthHalf-CystineHuman GeneticsImmuneImmunesKinasesL-CysteineLabelLearningLibrariesLigand BindingLigandsMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Skin NeoplasmMalignant TumorMedicationMedicinal ChemistryMedicineMelanomaMelanoma CellMetabolicMethodsModel SystemMolecularMolecular InteractionMonitorMutateMutationNeoplastic Disease Chemotherapeutic AgentsOncogenesOncogenesisOncogenicOutcomePatientsPharmaceutic ChemistryPharmaceutical ChemistryPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhosphotransferase GenePhosphotransferasesProliferatingProteinsProteomeProteomicsRNA ExpressionRNA SeqRNA sequencingRNAseqReactive SiteRegulationReporterResearchRoleShapesSiteSkin CancerStrains Cell LinesSynthesis ChemistrySynthetic ChemistryTechnologyTestingTissue GrowthTranscriptionTranscription Factor OncogeneTranscription Factor Proto-OncogeneTranscription factor genesTransforming GenesTransphosphorylasesTumor-Specific Treatment AgentsValidationVitamin Hanaloganti-cancer druganti-cancer researchanti-cancer therapybiologicbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquescancer researchcancer sub-typescancer subtypescancer therapycancer-directed therapychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcoenzyme Rcultured cell linedevelopmentaldrug discoverydrug interventiondrug treatmentdrug/agentfunctional genomicsgenome mutationimprovedinhibitormalignancymalignant skin tumormelanoma cancer modelmelanoma modelmelanoma tumor modelneoplasm/cancernext generationnovelontogenypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinical developmentpreclinical developmentprogramsprotein protein interactionsmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolespheroidssuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranscription factortranscriptome sequencingtranscriptomic sequencingtumortumorigenesisvalidations
Description preview
PROJECT SUMMARY/ABSTRACT
Advances in human genetics have identified 400+ genes that when amplified or mutated promote
tumorigenesis. While there has been substantial success in developing drugs for kinases and metabolic
enzymes deregulated in cancer, they represent only a tiny fraction of the cancer drivers discovered to date.
The vast majority…
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