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Identification of candidate genomic regulatory elements involved in oral clefts
Organization MARSHFIELD CLINIC, INC.Location MARSHFIELD, UNITED STATESPosted 14 Aug 2025Deadline 20 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025AP-2AP-2 Alpha GeneAP2 GeneAP2TFAffectAssayBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBioassayBiologicalBiological AssayBiological FunctionBiological ProcessBody TissuesCausalityCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationChIP SequencingChIP-seqChIPseqChromatinCleft LipCombining SiteCraniofacial AbnormalitiesDataDevelopmentEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEnhancersEnvironmental FactorEnvironmental Risk FactorEtiologyFunctional RNAFutureGWA studyGWASGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic HeterogeneityGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic TranscriptionGenetic predisposing factorGenetic propensityGenomic SegmentGenomicsGoalsHarelipHealthHistonesHumanInfluentialsInherited PredispositionInherited SusceptibilityKnowledgeLipLip structureLocationMapsMesenchymasMesenchymeModern ManMolecularMolecular InteractionMorphogenesisMutateMutation DetectionNetwork AnalysisNoncoding RNANontranslated RNAOutcomePalatePathway AnalysisPathway interactionsPatient CarePatient Care DeliveryPatientsPrecipitationProcessProteinsRNA ExpressionReactive SiteRegulator GenesRegulatory ElementRegulatory PathwayResearchSpecificityTFAP2TFAP2ATFAP2A geneTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTranscriptional Regulatory ElementsTranslatingUntranslated RNAbiologiccandidate identificationcare for patientscare of patientscaring for patientscausationcell typechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcleft lip and palatecleft lip/palatecleft palate/lipclinical carecraniofacialcraniofacial anomaliescraniofacial defectscraniofacial developmentcraniofacial malformationcraniofacial tissuecraniofaciesdata integrationde novo mutationde novo variantdevelopmentaldifferential expressiondifferentially expresseddisease causationenvironmental riskepigenomicsgenetic etiologygenetic mechanism of diseasegenetic risk factorgenetic trans acting elementgenetic vulnerabilitygenetically predisposedgenome scalegenome segmentgenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic regionhare liphuman dataimprovedin vitro Assayinherited factorinsightknock-downknockdownmachine learning based methodmachine learning methodmachine learning methodologiesmalformationmorphogenetic processnoncodingoral cleftpathwayprecipitationspromoterpromotorregulatory genespatial and temporalspatial temporalspatiotemporaltrans acting elementtranscription factortranscriptional differenceswhole genome association analysiswhole genome association study
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Project Summary/Abstract
Disturbances in the molecular pathways that control lip and palate development during embryogenesis
can lead to oral clefts, but knowledge of the regulatory interactions involved in modulating the expression
of genes in these pathways remains limited. Because enhancers are critical to the spatiotemporal
regulation of gene…
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