Humanized Mouse Core
Full Description
SUMMARY - HUMANIZED MOUSE CORE (CORE A)
The huNSG mouse model nicely recapitulates aspects of human biology that are not supported in other
systems. This humanized mouse model also offers the only small animal model capable of supporting HCMV
infection, latency, and reactivation. This PPG requires our highly standardized huNSG model in order to
effectively characterize unique conditions and quantitatively differentiate viral growth and dissemination of
different viral mutants and treatments. Core A will provide the infrastructure and knowledge required for
completion of the proposed research projects involving huNSG mice and standardize analysis between all
projects to allow for direct comparisons. By working directly with the Project leaders, Core A will aid in
designing and execution of the proposed experiments.
Grant Number: 5P01AI127335-09
NIH Institute/Center: NIH
Principal Investigator: Patrizia Caposio
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