grant
Human Mitochondrial Variation and Sudden Cardiac Arrest Risk and Resuscitation
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 12 Apr 2024Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AccountingAddressAllelesAllelomorphsApoptosisApoptosis PathwayArrhythmiaAsystoleAutopsyBiochemicalBiocompatible MaterialsBiomaterialsBrainBrain Nervous SystemCardiacCardiac ArrestCardiac ArrhythmiaCardiac Electrophysiologic TechniquesCardiac Electrophysiological DiagnosticsCardiac Muscle CellsCardiac MyocytesCardiocyteCardiopulmonary ResuscitationCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCausalityCell BodyCell RespirationCellsCellular RespirationCessation of lifeCharacteristicsCirculationClinicalCohort StudiesCommunitiesComplementComplement ProteinsComputational toolkitConcurrent StudiesCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisDNA copy numberDataDeaminaseDeathDevelopmentDisciplineDoseDysfunctionElectrophysiologyElectrophysiology (science)EncephalonEtiologyFunctional disorderGene AlterationGene MutationGene variantGeneticGenetic DiversityGenetic VariationGenomeH2O2HaplotypesHeartHeart ArrestHeart ArrhythmiasHeart Muscle CellsHeart myocyteHereditaryHumanHydrogen PeroxideHydroperoxideInheritedInjuryInvestigationIschemia-Reperfusion InjuryIschemic HeartIschemic Heart DiseaseIschemic myocardiumLeigh DiseaseLeigh SyndromeLinkMitochondriaMitochondrial DNAModern ManMyocardial IschemiaNHLBINational Heart, Lung, and Blood InstituteNeurologic statusNeurological statusNeurophysiology / ElectrophysiologyOrphan DiseaseOutcomeOxidative StressPathologicPhenotypePhysiopathologyPlayPopulationPreventionProgrammed Cell DeathProspective cohortPublic HealthRare DiseasesRare DisorderRecoveryReperfusion DamageReperfusion InjuryResuscitationRiskRisk FactorsRoleSeriesSomatic MutationSubacute Necrotizing EncephalomyelitisSubacute Necrotizing EncephalomyelopathySubacute Necrotizing EncephalopathySuperoxide AnionSuperoxide RadicalSuperoxidesSurvey InstrumentSurveysSurvivorsTOPMedTechnologyTestingTrans-Omics for Precision MedicineVariantVariationVentricular FibrillationWorkaerobic metabolismaerobic respirationallelic variantatherosclerotic coronary diseasebase editingbiological materialcardiac electrical activitycardiac electrophysiologycardiac ischemiacardiac resuscitationcardiomyocytecase-controlled studiescausationclinical materialcomplementationcomputational toolboxcomputational toolscomputational toolsetcomputerized toolscoronary arterial diseasecoronary ischemiadensitydevelopmentaldisease causationelectrophysiologicalgene defectgenetic associationgenetic variantgenomic variantheart electrical activityheart electrophysiologyheart ischemiaheart resuscitationheteroplasmyhiPSChigh riskhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimprovedinduced human pluripotent stem cellsinjuriesinnovateinnovationinnovativelow-frequency mutationmalleable riskmitochondrialmitochondrial genomemodel organismmodifiable riskmortalitymtDNAmultidisciplinarymutant allelemyocardial ischemia/hypoxiamyocardium ischemianecropsynovelorphan disorderoxidative metabolismpathophysiologypopulation basedpostmortempreventpreventingprospectiverare allelerare mutationrare variantresponserestorationsocial rolesomatic varianttherapeutic target
Description preview
Sudden cardiac arrest (SCA) is a major public health concern, accounting for up to 400,000 deaths each year.
While SCA cases are heterogeneous in etiology, the most common underlying pathologic substrate is ischemic
heart disease and the most common electrophysiologic mechanism is ventricular fibrillation (VF). Survival
following VF-SCA is less…
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