grant
Human Intestinal Organoids as a Model for Acute GI-ARS
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AcuteAcute Radiation SyndromeAgeAlimentary CanalAnatomic SitesAnatomic structuresAnatomyAssayBioassayBiologic ModelsBiological AssayBiological MarkersBiological ModelsCell BodyCell ComponentsCell DeathCell FunctionCell PhysiologyCell ProcessCell StructureCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StructuresCessation of lifeDNA Damage RepairDNA RepairDataDeathDefectDehydrationDevelopmentDiarrheaDigestive TractDiseaseDisorderDoseEffectivenessElectrolytesEmergenciesEmergency SituationEmesisEpitheliumEvaluationExposure toFDA approvedFluorescence AgentsFluorescent AgentsFluorescent DyesFutureGI Stem cellGI TractGastrointestinal TractGastrointestinal tract structureGeneral RadiologyGenerationsGeneticGenetic DiversityGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic VariationGoalsGrowth AgentsGrowth FactorGrowth SubstancesHandHealthHigh Throughput AssayHumanImageInbreedingIndividualInflammationIntervention StrategiesIntestinalIntestinesIonizing Electromagnetic RadiationIonizing radiationKineticsLabelLibrariesMarketingMicroscopeModalityModel SystemModelingModern ManMorbidityMorphologyNatural regenerationNauseaNetwork AnalysisOrganismOrganoidsPaintPathway AnalysisPhenotypePhysiologicPhysiologicalPopulationPositionPositioning AttributePredispositionPreparednessProbioticsProgenitor CellsProliferatingProteins Growth FactorsRadiationRadiation DoseRadiation Dose UnitRadiation InjuriesRadiation ToxicityRadiation exposureRadiation induced damageRadiation therapyRadiation-Ionizing TotalRadiologyRadiology SpecialtyRadiotherapeuticsRadiotherapyRadiotoxicityReadinessRecombinant DNA TechnologyRegenerationRegenerative responseRodentRodent ModelRodentiaRodents MammalsScanningSepsisSeveritiesSourceSubcellular ProcessSusceptibilitySymptomsTechniquesTestingTherapeuticTreatment EfficacyUnscheduled DNA SynthesisVillusVomitingWorkagesalimentary tractassess effectivenessbio-informatics pipelinebio-markersbioinformatics pipelinebiologic markerbiomarkerbiomarker identificationbiomarker signaturebiomarker validationbody water dehydrationbowelclinical effectco-exposuresco-morbidco-morbidityco-occurring exposurecohortcombined exposurecomorbiditycomplex exposureconcurrent exposuredetermine effectivenessdetermine efficacydevelopmentaldigestive canaleffectiveness assessmenteffectiveness evaluationefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationepithelial repairepithelium regenerationevaluate effectivenessevaluate efficacyexamine effectivenessexamine efficacyexposure mixturefluorescent dye/probegastrointestinalgastrointestinal stem cellgenetically engineeredgut progenitorgut stem cellhandshigh throughput screeninghuman derived modelhuman derived platformhuman derived systemhuman like modelhuman like platformhuman like systemhuman modelhuman specific alternativehuman specific modelhuman specific platformhuman specific systemhuman-based alternativehuman-based biological modelshuman-based modelhuman-based nonanimal modelshuman-based platformhuman-based researchhuman-based systemhuman-based toolshuman-centered modelhuman-centered platformhuman-centered researchhuman-centered systemhuman-focused researchhuman-relevant alternativehuman-relevant modelhuman-relevant platformhuman-relevant systemidentification of biomarkersidentification of new biomarkersimagingimaging approachimaging based approachin vitro Modelin vivoindividual heterogeneityindividual variabilityindividual variationinnovateinnovationinnovativeinsightintervention efficacyintestinal barrierintestinal epitheliumintestinal mucosal barrierintestinal progenitorintestinal stem cellsionizing outputirradiationirradiation injuryirradiation responseliving systemmarker identificationmarker validationmedical countermeasuremicrobialmixed exposuremodel of humanmortalitymultiomicsmultiple omicsnecrocytosisnovelpanomicsphenotypic biomarkerphenotypic markerpre-clinicalpreclinicalradiation countermeasureradiation damageradiation mitigationradiation poisoningradiation responseradiation treatmentradiological countermeasureradiological mitigationradiomitigationregenerateregenerate epitheliumregeneration responserepairrepairedresponseresponse to radiationscreeningscreeningssexsimultaneous exposuresstem cellstherapeutic efficacytherapy efficacytranslational opportunitiestranslational potentialtreatment with radiation
Description preview
PROJECT SUMMARY
Gastrointestinal acute radiation syndrome (GI-ARS) is a consequence of exposure to high doses of ionizing
radiation and is characterized by extensive damage to the intestinal epithelium that leads to loss of barrier
function, sepsis, and in some cases mortality. Currently there is a critical need to develop new physiologically…
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