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Human Genetics of Tuberculosis
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Jul 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025(TNF)-αAccountingAffectAfricanAllelesAllelic LossAllelomorphsAlveolar MacrophagesBiochemicalBlood leukocyteCachectinCandidate Disease GeneCandidate GeneCausalityCell BodyCell LineCellLineCellsClinicalCodeCoding SystemCollaborationsCollectionComplementary DNAComputer AnalysisComputing MethodologiesCytometryDataData BasesDatabasesDevelopmentDiseaseDisorderDrynessEast AsianEdodekin AlfaEpidemiologyEthnic OriginEthnicityEtiologyEuropeanExposure toFamilyFibroblastsGWA studyGWASGene variantGenesGeneticGenetic HeterogeneityGenetic PolymorphismGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGenetic studyGenotypeHLA-DRB1HLA-DRB1 antigenHaitiHaitianHealthHumanHuman GeneticsIFN-GammaIFN-gIFN-γIFNGIFNγIL-12IL-23IL12Immune InterferonImmune responseImmunityImmunochemical ImmunologicImmunologicImmunologic SubtypingImmunologicalImmunologicallyImmunologicsImmunophenotypingImpairmentIn VitroIndividualIndividuals from minorityIndividuals of minorityInfectionInherited PredispositionInherited SusceptibilityInterferon GammaInterferon Type IIInterleukin-12InvestigationKnowledgeLeukocytesLeukocytes Reticuloendothelial SystemLoss of HeterozygosityM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMacrophage-Derived TNFMarrow leukocyteMinorityMinority GroupsMinority PeopleMinority PopulationMinority individualModelingModern ManMolecularMonocyte-Derived TNFMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMφNGS MethodNGS systemNKSFNatural Killer Cell Stimulatory FactorPathogenesisPathway interactionsPatient RecruitmentsPatientsPenetrancePharmacologyPopulationPopulation HeterogeneityPredispositionPreventivePrimary ImmunodeficiencyPrimary InfectionProbabilityProductionProteinsProxyPulmonary MacrophagesRNA SeqRNA sequencingRNAseqRecurrenceRecurrentRelapseReportingRiskRoleSamplingSiblingsStrains Cell LinesSusceptibilityTB infectionTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTYK2TechniquesTechnologyTestingTherapeuticTuberculosisTumor Necrosis FactorTumor Necrosis Factor-alphaVariantVariationWhite Blood CellsWhite Cellallelic variantautosomecDNAcandidate identificationcausal allelecausal genecausal mutationcausal variantcausationcausative mutationcausative variantcell typecomputational analysescomputational analysiscomputational methodologycomputational methodscomputer analysescomputer based methodcomputer methodscomputing methodcongenital immune deficiencycongenital immunodeficiencycultured cell linedata basedevelop softwaredeveloping computer softwaredevelopmentaldisease causationdisseminated TBdisseminated tuberculosisdiverse populationsentire genomeepidemiologicepidemiologicalexome sequencingexome-seqexperimentexperimental researchexperimental studyexperimentsfull genomegenetic epidemiologic studygenetic epidemiologygenetic etiologygenetic immune defectgenetic immune deficiencygenetic immunodeficiencygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenome scalegenome sequencinggenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic variantheterogeneous populationhigh dimensionalityhost responsehypoimmunityiPSiPSCiPSCsimmune deficiencyimmune system responseimmunodeficiencyimmunopathologyimmunoresponseinborn errors in immunityinborn errors of immunityinborn immunodeficiencyinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinfection due to Mycobacterium tuberculosisinherited immune defectinherited immune deficiencyinherited immunodeficiencyinterleukin-23kindredlFN-Gammalatency/reactivationloss of functionmouse modelmtbmurine modelnext gen sequencingnext generation sequencingnextgen sequencingnovelparticipant recruitmentpathogenpathwaypolymorphismpopulation diversityprimary immune defectprimary immune deficiencyreactivation from latencyrecruitresponsesecondary infectionsocial rolesoftware developmentstemtranscriptome sequencingtranscriptomic sequencingtuberculosis infectiontuberculous spondyloarthropathywhite blood cellwhite blood corpusclewhole genomewhole genome association analysiswhole genome association study
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Project Summary
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a major health problem. About a quarter of
the world population is infected, yet only a minority develop TB, either during primary infection, or later during
secondary infection or reactivation of latent Mtb. Genetic epidemiological evidence strongly suggests that TB…
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