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HTS with Aspergillus fumigatus for novel, mold-active antifungals

Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 12 Jun 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025A fumigatusA. fumigatusAMP KinaseATP-AMP PhosphotransferaseATP-AMP TransphosphorylaseAddressAdenylokinaseAffectAspergillus fumigatusAssayBioassayBiological AssayBiomassBlindnessC albicansC. albicansC.albicansCandida albicansCell BodyCell LineCellLineCellsChemicalsClinicalCorneaCorneal infectionCytolysisDeath RateDevelopmentDevicesDiseaseDisease OutcomeDisorderDrug ScreeningDrug resistanceEnzyme GeneEnzymesFilamentFilamentous FungiFunding OpportunitiesFungal Drug ResistanceFungus DiseasesFungus drug resistantFutureGeneralized GrowthGenerationsGenetic ScreeningGerminationGoalsGrowthHematopoieticHigh Throughput AssayHumanImmuneImmunesIn VitroIndividualInfectionIowaKeratitisKineticsLibrariesLifeLiquid substanceLuciferase ImmunologicLuciferasesLysisMammalian CellMeasurementMeasuresMedicalMicrobial keratitisModern ManMoldsMorbidityMorbidity - disease rateMycosesMyokinaseNeurofibrillary TanglesOperative ProceduresOperative Surgical ProceduresOpticsOrganismPathway interactionsPatientsPredispositionResistanceSeverity of illnessSolidSteroid CompoundSteroidsStrains Cell LinesSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTestingTherapeutic FungicidesTherapeutic IndexTissue GrowthToxic effectToxicitiesUniversitiesWorkYeastsadenylate kinaseanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantcandidate identificationchemical geneticschemical librarychemotherapycohortcornealcultured cell linedensitydesigndesigningdevelopmentaldisease severitydrug developmentdrug discoverydrug resistantdrug-like chemicaldrug-like compounddrug-like moleculefallsfightingfluidfungal infectionfungus drug resistancefungus infectionhemopoietichigh throughput screeninginfections in the corneainfectious keratitisliquidliving systemmortalitymortality ratemortality ratiomutantneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologynovelontogenyopticalorgan transplant patientorgan transplant recipientpathwaypatient populationpre-clinical developmentpreclinical developmentresistance to Drugresistance to anti-fungalresistantresistant to Drugresistant to anti-fungalscaffoldscaffoldingscreeningscreeningssmall molecule librariessurgerytanglevision lossvisual loss

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Description preview

PROJECT SUMMARY
Molds cause devastating infections in diverse patient populations worldwide. The most life-threatening of
these diseases are invasive mold infections (IMIs) which primarily affect immune compromised individuals
including those undergoing chemotherapy, long term steroid treatment, and hemopoietic or solid organ transplant
patients.…

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