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How myelin regulates vestibular circuit function and balance behaviors

Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 1 Mar 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AcuteAddressAffectAssayAxonBehaviorBehavioralBioassayBiological AssayBrachydanio rerioCell BodyCell Surface ProteinsCellsDanio rerioDataDemyelinating DiseasesDemyelinating DisordersDemyelinationsDevelopmentDiseaseDisorderDisseminated SclerosisDrugsEnsureEquilibriumFunctional ImagingGliaGlial CellsGoalsImageImpairmentKolliker's reticulumLaboratoriesLarvaLesionLightLinkMS patientMeasurementMeasuresMedicationMethodsMicroscopyMissionModelingMolecularMonitorMotionMultiple SclerosisMyelinNational Institutes of HealthNatureNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronsNeurophysiology - biologic functionNon-neuronal cellNonneuronal cellOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOpticsPharmaceutical PreparationsPharmacologyPhasePhotoradiationPhysiologic ImagingPopulationPosturePublic HealthReagentRecoveryRecovery of FunctionReflexReflex actionResearchResearch ResourcesResourcesRoleRunningShapesTechnologyTestingTherapeuticTimeTrainingTransgenic OrganismsUnited States National Institutes of HealthVestibularVestibular System FunctionVestibular functionWorkZebra DanioZebra FishZebrafishbalancebalance functionbehavior testbehavioral testclinical significanceclinically significantde-myelinating diseasesde-myelinating disordersdemyelinatedemyelinating conditionsdemyelination diseasesdemyelination disordersdevelopmentaldrug/agentexperimentexperimental researchexperimental studyexperimentsfunctional recoverygenetic approachgenetic strategyhigh rewardhigh riskimagingin vivoinhibitorinsular sclerosismultiple sclerosis patientmyelinationnerve cementneural circuitneural circuitryneural functionneurocircuitryneuronalneuronal circuitneuronal circuitrynew technologynovelnovel technologiesopticalpatients with MSpatients with multiple sclerosispeople with Multiple sclerosispharmacologicphysiological imagingpost-doctoral trainingposture instabilitypreventpreventingre-myelinatere-myelinationremyelinateremyelinationresponserestorationsocial rolesynaptic circuitsynaptic circuitrytooltransgenicvestibular system

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Description preview

SUMMARY/ABSTRACT
Loss of myelin, as seen in conditions like multiple sclerosis, frequently leads to balance issues. These dis-

ruptions in balance are attributed to the compromised function of neural circuits associated with the vestibu-

lar system. Despite the clinical significance of this problem, our understanding of how myelin loss affects the…

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How myelin regulates vestibular circuit function and balance behaviors β€” NEW YORK UNIVERSITY SCHOOL OF MEDICINE | UNITED | Dev Procure