grant
How do Astrocytes Release ATP?
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 11 May 2026Deadline 10 May 2029
NIHUS FederalResearch GrantFY2026ANOVAAcuteAdenosineAdenosine ReceptorsAdenosine TriphosphateAdenylpyrophosphateAdrenergic AgentsAdrenergic DrugsAdrenergicsAffectAnalysis of VarianceAnimal BehaviorAstrocytesAstrocytusAstrogliaBathingBathsBehaviorBenemidBiologic ModelsBiological ModelsBiosensorBrachydanio rerioBrainBrain Nervous SystemCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalciumCas nuclease technologyCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsCellular MembraneCloningClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommunicating JunctionCommunicationCoupledCuesDanio rerioDataDephosphinDrosophilaDrosophila genusDynaminE-stimEducational process of instructingElectric StimulationEncephalonEventExocytosisExposure toFamilyFamily memberFliesFluorescenceGap JunctionsGene FamilyGene Transfer TechniquesGenesGeneticGenotypeGlutamatesGoalsHumanHydrogen OxideImageIn VitroIntracellular Communication and SignalingInvertebrataInvertebratesInvestigatorsKnock-outKnockoutL-GlutamateLarvaLeadLeadershipLevarterenolLevonorepinephrineLow-resistance JunctionMediatingMembraneMentorshipMiceMice MammalsModel SystemModelingModern ManMurineMusNerveNerve CellsNerve Transmitter SubstancesNerve UnitNervous SystemNeural CellNeurocyteNeurohumor ReceptorsNeurologic Body SystemNeurologic Organ SystemNeuromediator ReceptorsNeuronsNeuroregulator ReceptorsNeurotransmitter ReceptorNeurotransmittersNexus JunctionNoradrenalineNorepinephrineNorsympatolNorsynephrineOctopamineOrthologOrthologous GeneP1 PurinoceptorsPb elementPermeabilityPost-Transcriptional Gene SilencingProbenecidPurinergic P1 ReceptorsRNA InterferenceRNA SilencingRNAiReceptor ProteinRecyclingResearchResearch PersonnelResearch ResourcesResearchersResourcesRoleSequence-Specific Posttranscriptional Gene SilencingSignal InductionSignal TransductionSignal Transduction SystemsSignalingSynapsesSynapticSynaptic VesiclesTRP channelTeachingTechnical ExpertiseTemperatureTestingTextTrainingTransgenesisTransient receptor potential channelTyramineVariance AnalysesVesicleViral DiseasesVirus DiseasesWaterWorkZebra DanioZebra FishZebrafishastrocytic gliabiological sensorbiological signal transductionbrain cellcell culturecell culturescell typechannel blockerselectrostimulationex vivo imagingexperimentexperimental researchexperimental studyexperimentsextracellularflyfruit flygene manipulationgenetic manipulationgenetically manipulategenetically perturbglutamatergicheavy metal Pbheavy metal leadimagingin vivoinsightknock-downknockdownmembermembrane structuremodel organismmutantneural circuitneural circuitryneural controlneural regulationneurocircuitryneuromodulationneuromodulatoryneuronalneuroregulationoverexpressoverexpressionpreventpreventingreceptorresponseskillssocial rolesynapsesynaptic circuitsynaptic circuitrytechnical skillsvesicle releasevesicular releaseviral infectionvirus infectionvirus-induced diseasevoltage
Description preview
Project Summary
Astrocytes respond to neuronal activity via various neurotransmitter receptors, triggering intracellular calcium increases in
astrocytes that are both necessary and sufficient to induce changes in neural circuit activity and behavior. Substantial
evidence from several model organisms has suggested that purinergic signaling is…
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