grant
Host-pathogen-microbiome interactions in Mycoplasma genitalium infection, pathology, and treatment: experiments in a 3D organotypic cervical epithelium model to strengthen clinical guidelines
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 24 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsBacteriaBacterial VaginitisBacterial VaginosisC trachomatisC. trachomatisCannot achieve a pregnancyCaringCell BodyCellsCervicalCervicitisChlamydia trachomatisClinicalClinical DataCo-cultureCocultivationCocultureCoculture TechniquesDataDifficulty conceivingDrugsElementsEpidemiologic MethodologyEpidemiologic MethodsEpidemiologic research methodologyEpidemiologic research methodsEpidemiological MethodsEpidemiological TechniquesEpidemiological dataEpidemiology dataEpitheliumFlagylGene ExpressionGenesGenomicsGoalsGuidelinesHealthHumanImmune responseIn VitroIndividualInfectionInfertilityInflammationInflammatoryInvestigatorsKnowledgeLactobacillusLinkM genitaliumM. genitaliumMeasuresMediatingMedicationMentorsMethods EpidemiologyMethods in epidemiologyMetronidazoleMicroscopyMiscellaneous AntibioticModelingModern ManMolecularMycoplasma InfectionsMycoplasma genitaliumNatural HistoryNitroimidazolesNonspecific VaginitisOutcomePathogenicity FactorsPathologyPelvic Inflammatory DiseasePharmaceutical PreparationsPhysiologyPopulationPrevalencePreventative strategyPrevention strategyPreventive strategyRecommendationReproductive HealthResearchResearch PersonnelResearchersResistanceResistance to antibioticsResistant to antibioticsRickettsia trachomaeRoleSatricSexual TransmissionSexually Transmitted DiseasesSexually Transmitted DisorderSexually Transmitted InfectionStructureTestingTinidazoleTrainingTranslatingTreatment outcomeUterusVaginaVenereal DiseasesVenereal DisordersVenereal InfectionsVirulence FactorsWomanadverse consequenceadverse outcomeantibiotic drug resistanceantibiotic resistantbacterial communitybiological adaptation to stresscareercervicovaginalclinical careclinical relevanceclinically actionableclinically relevantco-infectioncoinfectioncommunity spreadcommunity transmissioncommunity-level spreadcommunity-level transmissiondrug/agentepidemiologic dataexperimentexperimental researchexperimental studyexperimentsfemale infectionsfemale outcomesfertility cessationfertility losshost microbiotahost microflorahost responseimmune system responseimmunoresponseimprovedin vitro Modelin vivoinfected femalesinfected with Mycoplasmainfected womeninfections among womeninfections in femalesinfections in womeninfertileinnovateinnovationinnovativemicrobial consortiamicrobial floramicrobiomemicrobiotamicrofloramultiomicsmultiple omicsmultispecies consortianon-specific vaginitisnoveloutcomes among femalesoutcomes among womenoutcomes in femalesoutcomes in womenpanomicspathogenpelvic inflammation diseasepelvic inflammation disorderpelvic inflammatory disorderpelvic inflammatory syndromepreventpreventingreaction; crisisreproductive outcomeresident microbesresident microfloraresistantresponsescreeningscreeningssexually acquired infectionsexually transmittedsocial rolestress responsestress; reactionsuccesssynergismthree dimensionaltranscriptomicstreatment guidelineswombwomen experiencing infectionswomen infectionswomen with infectionswomen's outcomes
Description preview
Mycoplasma genitalium (MG) is an emerging sexually transmitted pathogen whose clinical outcomes in women
are poorly understood. Unlike Chlamydia trachomatis (CT), the CDC does not recommend MG screening for
asymptomatic women because it is unclear how often asymptomatic MG leads to adverse reproductive outcomes
like cervicitis, which can lead to…
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